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Table 1 Information of articles

From: The global prevalence of primary central nervous system tumors: a systematic review and meta-analysis

Rows

Name [references]

Country

Year of publication

Participants

Prevalence

1

Seung Hoon Lee [34]

South Korea

2017

654

Germ cell tumors (pituitary adenomas: 6.7%, pineal tumor: 34.5%, Brain tumor: 35%)

2

Yeon-Lim Suh [25]

Korea

2002

3221

Pituitary adenomas: 19%, meningioma: 24%, tumors of neuroepithelial tissue: 31.6%(embryonal tumors: 2.6% MEDULLOBLASTOMA: 1.8%, ependymal tumors: 1.8%, glial tumor of CNS and pineal gland: 2.3%, astrocytic tumors of CNS: 8.9%, oligodendroglial: 3.3%, choroid plexus: 0.4%, glioblastoma: 10.6%), germ cell tumors: 1.7%

3

Yeon-Lim Suh [25]

Korea

2002

2556

Pituitary adenomas: 15.1%, meningioma: 25.1%, tumors of neuroepithelial tissue: 34.9%(glioblastoma: 4.8%, glial tumor of CNS and pineal gland: 0.35%, astrocytic tumors of CNS: 15.9%, oligodendroglial: 4.6%, choroid plexus: 0.4%, embryonal tumors: 3.3%, ependymal tumors: 2.4%) germ cell tumors: 1.7%

4

Anirban Ghosh [42]

India

2004

873

Brain tumor [glioma: 60% (ependymal tumors: 3.2%, astrocytic tumors of CNS: 36.7%, oligodendroglial: 4.9%), meningioma: 11.6%, pineal tumor: 0.2%, medulloblastoma: 1.6%, pituitary adenomas: 4.1%]

5

Axel Tjo¨ rnstrand [43]

Sweden

2014

592

Pituitary adenomas: 100%

6

Adrian F. Daly [44]

Belgium

2006

68

Pituitary adenomas: 100%

7

Kullapat Veerasarn [45]

Thailand

2016

93,810

Pituitary adenomas: 3.8%, meningioma: 15.3%, pineal tumor: 1.9%

8

Kurupath Radhakrishnan [46]

USA

1995

339

Pituitary adenomas: 16.2%, glioma: 29.4% (ependymal tumors: 1.1%, astrocytic tumors of CNS: 24.7%, oligodendroglial: 3.2%), meningioma: 40.1%, schwannoma: 4.4%, medulloblastoma: 1.7%

9

T.B. Johannesen [36]

Norway

2004

14,641

Pituitary adenomas: 9.3%, meningioma: 21.9%, pineal tumor: 0.7%, brain tumor: 60.1%, spinal tumor: 1.9%

10

Yun-Sik Dho [41]

Republic of Korea

2017

11,827

10 pituitary adenomas: 17.9%, meningioma: 37.2%, tumors of neuroepithelial tissue: 13.6% (glioma: 12.6%, ependymal tumors: 0.9%, glial tumor of CNS and pineal gland: 1.07%, astrocytic tumors of CNS: 2.03%, oligodendroglial: 1.2%, choroid plexus: 0.16, glioblastoma: 5.3%, pilocytic astrocytomas : 0.4%), germ cell tumors: 1.07%

11

Ahmad F. Tamimi [47]

Jordan

2015

313

Pituitary adenomas: 9.2%, embryonal tumors: 7.02 (medulloblastoma: 4.7%), meningioma: 26.1%, tumors of neuroepithelial tissue: 37.6 (ependymal tumors: 1.5%, astrocytic tumors of CNS: 9.2%, oligodendroglial: 1.2%, choroid plexus: 0.3%, glioblastoma: 18.8%, pilocytic astrocytomas: 3.8%), schwannoma: 3.8%

12

Leonard T. Kurland [48]

USA

1982

223

Pituitary adenomas: 13%, glioma: 34.9%, meningioma: 39.4%

13

Leonard T. Kurland [48]

USA

1982

189

Pituitary adenomas: 12.1%, glioma: 35.9%, meningioma: 39.6%

14

Chang-Hyun Lee [2]

Korea

2010

5,692

Pituitary adenomas: 13.8, meningioma: 29.6%, tumors of neuroepithelial tissue: 19.3% (glioma: 1.9%, embryonal/primitive /medulloblastoma: 1.2%, ependymal tumors: 1.1%, glioblastoma: 5.9%, astrocytic tumors of CNS: 4.8%, oligodendroglial: 1.05%, choroid plexus: 0.26%)

15

Haley Gittleman [16]

USA

2014

51,125

Pituitary adenomas: 100%

16

NUNG WON CHOI [49]

USA

1970

760

Pituitary adenomas: 2.6%, glioma: 56.7% (ependymal tumors: 2.8%, astrocytic tumors of CNS: 17.5%, Oligodendroglial: 1.3%, glioblastoma: 20.9%, medulloblastoma: 2.5%), meningioma: 6.8%

17

David Gigineishvili

[21]

Georgia

2013

980

Pituitary adenomas: 11.7%, meningioma: 25.9%, tumors of neuroepithelial tissue: 13.1% (glioblastoma: 4.8%, ependymal tumors: 0.4%, astrocytic tumors of CNS: 3.3%, oligodendroglial: 1.22%)

18

D.Gigineishvili [50]

Georgia

2013

473

Pituitary adenomas: 17.9%, meningioma: 45.2%, glioblastoma: 9.9%

19

Ramandeep S. Arora [51]

England

2009

54,336

Pituitary adenomas: 8.8%, meningioma: 15.8%, pineal tumor: 0.38%, tumors of neuroepithelial tissue: 53% (embryonal tumors: 1.5% (medulloblastoma: 1.07%), ependymal tumors: 1.96%, astrocytic tumors of CNS: 35.2% (glioblastoma: 21.7%, pilocytic astrocytomas: 1.68%), oligodendroglial: 12.2%, choroid plexus: 0.18%), tumors of cranial and spinal nerves: 6.8%

20

Alberto Fernandez [52]

England

2010

63

Pituitary adenomas: 100%

21

Giuseppe D 'Alessandro [53]

Italy

1995

178

Pituitary adenomas: 14%, meningioma: 37%, tumors of neuroepithelial tissue: 34.8%

22

Amélie Darlix [54]

France

2017

57,816

Pituitary adenomas: 3.7%, meningioma: 7.1%, tumors of neuroepithelial tissue: 43.5% (glioma: 39.1%, embryonal tumors: 1.6% (medulloblastoma: 0.95%), ependymal tumors: 2.3%, astrocytic tumors of CNS: 26.5% (glioblastoma: 21.4%), oligodendroglial: 5.9%, choroid plexus: 0.3%), germ cell tumors: 0.4%, schwannoma: 8.6%

23

Hideo Nakamura [39]

Japan

2011

5,448

Pituitary adenomas: 17.8%, glioma: 19.5%, meningioma: 36.7%, schwannoma: 9.9%, medulloblastoma: 0.45%

24

Dale L. Preston [37]

Japan

2002

467

Pituitary adenomas: 7.49%, glioma: 9.2%, meningioma: 18.8%, schwannoma: 11.3%

25

Charles A. Stiller [17]

Great Britain (England, Scotland and Wales)

2019

4166

Pituitary adenomas: 1.6%, embryonal tumors: 2.6%, ependymal tumors: 6.98%, meningioma: 1.2%, pineal tumor: 1.1%, astrocytic tumors of CNS: 40.9% (glioblastoma: 3.5%, pilocytic astrocytomas: 20.6%) oligodendroglial: 0.8%, choroid plexus: 2.6%, germ cell tumors: 4%, atypical teratoid/rhabdoid tumors: 1.94%, medulloblastoma: 12.5%

26

Tanya S. Surawicz [55]

USA

1999

20,765

Pituitary adenomas: 8%, meningioma: 25.3%, tumors of neuroepithelial tissue: 51.2% (glioma: 3.6%, embryonal tumors: 1.8%, ependymal tumors: 2.36%, glial tumor of CNS and pineal gland: 1.2%, astrocytic tumors of CNS: 8.1%, oligodendroglial: 2.6%, choroid plexus: 0.3%, glioblastoma: 22.6%, medulloblastoma: 1.8%, pilocytic astrocytomas: 1.78%), spinal tumor and tumors of cranial nerves: 6.5%

27

Emily A.J. Sehmer [19]

England

2014

435

Glioma (astrocytic tumors of CNS: 9.6% (glioblastoma: 86.4%), oligodendroglial: 0.4%)

28

Luc Bauchet [20]

France

2009

1017

Glioma: 51.7% (astrocytic tumors of CNS: 32.3% (glioblastoma: 2.3%, pilocytic astrocytomas: 23.1%), oligodendroglial: 6.5%, ependymal tumors: 8.4%), embryonal tumors: 19% (medulloblastoma: 14.9, atypical teratoid/rhabdoid tumors: 1.08%), glioneuronal tumor: 8.3%, meningioma: 2.3%, pineal gland: 1.08%, choroid plexus: 2.8%, germ cell tumors: 3.5%, Schwannoma: 2.3

29

David J. Cote [56]

USA

2019

97,810

Glioma (ependymal tumors: 6.7%, nonglioblastoma astrocytomas: 20.4, oligodendroglial: 8%, glioblastoma: 57.4%)

30

S Preston-Martin [57]

USA

1989

8612

Glioma: 50.1% (ependymal tumors: 1.3%, astrocytic tumors of CNS: 23.1%, oligodendroglial: 1.5%, glioblastoma: 18.2%, medulloblastoma: 2.2%), meningioma: 28%

31

K. Gousias [58]

Greece

2009

56

Glioma: 100%

32

Faith G. Davis [32]

USA

2001

6908

Glioma: 3.5%, embryonal tumors: 1.4%, ependymal tumors: 1.3%, meningioma: 26.5%, astrocytic tumors of CNS: 6.3%, oligodendroglial: 1.7%, glioblastoma: 22.3%, pilocytic astrocytomas: 1.3%

33

Yoshikazu Okamoto [59]

Switzerland

2004

122

Glioma (oligodendroglial: 40.9%)

34

Emmanuel Desandes [33]

France

2014

3886

Glioma: 6.7%, ependymal tumors: 6.4%, meningioma: 1.5%, oligodendroglial: 4.1%, choroid plexus: 2.7%, glioblastoma: 1.6%, germ cell tumors: 5.6%, atypical teratoid/rhabdoid tumors: 2.4%, medulloblastoma: 13.7%, pilocytic astrocytomas: 21.8%

35

Kenneth R. Hess [60]

USA

2004

22,427

Glioma: 2.8%, astrocytic tumors of CNS: 36.6%, oligodendroglial: 6.04%, glioblastoma: 52.02

36

M. P. W. A. Houben [61]

the Netherlands

2006

11,812

Glioma: (ependymal tumors: 3.2%, oligodendroglial/mixed glioma: 11.8%)

37

Helle Collatz Christensen [18]

DENMARK

2003

11,935

Glioma: 100% (meningioma: 40.59)

38

Janhvi Jaiswal [27]

India

2016

4295

Glioma: 34.1%, ependymal tumors: 2.2%, astrocytic tumors of CNS: 3.1%, oligodendroglial: 9.5%, glioblastoma: 12.9%, pilocytic astrocytomas: 2.07%

39

Faith G. Davis [62]

USA

1996

8,070

Glioma: 5.3%, ependymal tumors: 1.6%, meningioma: 21.1%, pineal tumor: 0.16%, astrocytic tumors of CNS: 19.7%, oligodendroglial: 2.1%, glioblastoma: 25.4%, medulloblastoma: 1.8%, pilocytic astrocytomas: 1.5%

40

Tola MR [63]

Italy

1994

169

Glioma (ependymal tumors: 1.7%, astrocytic tumors of cns: 16.5%, oligodendroglial: 7.6%, glioblastoma: 48.5%)

41

Camille Pouchieu [29]

France

2018

3515

Meningioma: 37.5%, tumors of neuroepithelial tissue: 42.5% (glioma: 4.03%, ependymal tumors: 1.9%, pineal tumor: 0.08%, astrocytic tumors of CNS: 4.2%, oligodendroglial: 0.79%, choroid plexus: 0.28%, glioblastoma: 26.8%, pilocytic astrocytomas: 0.96%), germ cell tumors and cysts: 0.5%, cranial and spinal nerve tumors: 12%,

42

Kimberly R. Porter [64]

USA

2010

18 037

Glioma: 33.2%, meningioma: 32.8%

43

Susan preston-martin [65]

USA

1990

462

Glioma: 28.3%, ependymal tumors: 15.1%, meningioma: 42.8%, astrocytic tumors of CNS: 11.25%

44

Adele Caldarella [30]

Italy

2011

4,417

Embryonal tumors: 0.7%, ependymal tumors: 0.9%, meningioma: 27.8%, pineal tumor: 0.02%, astrocytic tumors of CNS: 25.3%, oligodendroglial: 1.3%, choroid plexus: 0.02%, germ cell tumors: 0.02%

45

Rafael Fuentes-Raspall [66]

Spain

2011

679

Embryonal tumors: 3.5%, ependymal tumors: 1.9%, Astrocytic tumors of CNS: 35.7%, oligodendroglial tumors and mixed histologies: 2.5%, choroid plexus: 0.14%

46

Sarah Khan [67]

United Arab Emirates

2020

744

Embryonal tumors: 13.03%, ependymal tumors: 6.18%, meningioma: 4.1%, astrocytic tumors of CNS: 69.6%(diffuse astrocytic and oligodendroglial tumors: 64.9%), choroid plexus: 0.5%, germ cell tumors: 1.7%

47

Emanuele Crocetti [26]

Austria, Iceland, Ireland, Malta, Norway, Slovakia, Slovenia, Sweden, Northern Ireland, Scotland and Wales and Other 10 countries

2012

44,947

Embryonal tumors: 4.1%, ependymal tumors: 3.59%, astrocytic tumors of CNS: 85.9%, oligodendroglial: 6.4%, choroid plexus: 0.1%

48

Gillian C. Cole [68]

Wales

1989

526

Ependymal tumors: 4.7%, pineal tumor: 0.9%, astrocytic tumors of CNS: 52.6%, oligodendroglial: 6.8%, germ cell tumors: 0.7%, medulloblastoma: 1.7%

49

Kate A. Schellinger [22]

USA

2008

3,226

Spinal tumor: 69.9% (ependymal tumors: 23%, meningioma: 29%)

50

Linh M. Duong [69]

USA

2012

11,712

Ependymal tumors: 21.1%, meningioma: 32.6%, spinal tumor: 26.6%, pilocytic astrocytomas: 1.6%

51

Naseem Ahmed [70]

Pakistan

2007

81

Ependymal tumors: 9.8%, astrocytic tumors of CNS: 35.8%, oligodendroglial: 1.2%, glioblastoma multiforme: 3.7%,

pilocytic astrocytomas: 14.8%

52

Peter Kaatsch [24]

Germany

2001

3268

Ependymal tumors: 10.3%, meningioma: 1.16%, pineal tumor: 1.3%, astrocytic tumors of CNS: 41.7%

53

Therese A. Dolecek [23]

USA

2015

51,065

Meningioma: 100%

54

Bernd Holleczek [71]

Germany

2019

992

Meningioma: 100%

55

S. Zouaoui [72]

France

2018

13,038

Meningioma: 100%

56

Luis Eduardo Werneck de Carvalho [73]

Brazil

2017

949

Meningioma: 24.9%, tumors of neuroepithelial tissue: 40%, germ cell tumors: 0.9%

57

Mousa Taghipour [74]

Iran

2010

371

Meningioma: 100%

58

Lars Klaeboe [75]

Denmark, Finland, Norway and Sweden

2005

18,630

Meningioma: 100%

59

Lona C [31]

Italy

1988

182

Meningioma: 28.5%, tumors of neuroepithelial tissue: 56.04%, germ cell tumors: 1.09%

60

CHRISTOPH BURKHARD [40]

Switzerland

2003

196

Pilocytic astrocytomas: 28%

61

Keishi Makino [76]

Japan

2013

6,615

Pineal tumor: 0.46%, germ cell tumors: 1.05%

62

Donna L. Johnston [77]

Canada

2014

574

Medulloblastoma: 100%

63

Yousef S. Khader [35]

Jordan

2018

2096

Brain tumor: 100%

64

Maria Teresa GIORDANA [78]

Italy

1999

45

Medulloblastoma: 68.8%

65

JIANG Tao [79]

China

2011

636

Brain tumor: 100%

66

S. Cordera [80]

Italy

2002

253

Tumors of neuroepithelial tissue: 35.1%

67

Adalberto Miranda-Filho [81]

Brazil, France

2017

78,034

Primary CNS tumors: 100%

68

Sandrine Elia-Pasquet [82]

France

2004

329

Brain tumor: 92.4%, spinal tumor: 7.5%

69

Birthe Krogh Rasmussen [83]

Denmark

2017

1930

Astrocytic tumors of CNS: 15.5%, oligodendroglial: 5.9%, glioblastoma: 70.6%, pilocytic astrocytomas: 1.8%

70

Hyeon Jin Park [84]

Korea

2016

2,116

Germ cell tumors: 54.3%

71

Rose Lai [85]

USA

2008

454

Medulloblastoma: 100%

72

Agne` s Fleury [86]

France

1997

1376

Astrocytic tumors of CNS: 68.3%

73

Abbas Rezaianzadeh [87]

Iran

2020

1043

Brain tumor: 100%

74

Malene Schjønning Nielsen [28]

Denmark

2009

1,304

Oligodendroglial: 100%

75

Marios K. Georgakis [88]

12 SEE countries (Belarus, Croatia, Cyprus, Malta, Montenegro, Greater Poland, Portugal Central, Portugal North, Romania-Cluj, Romania-Iasi, Serbia Central, Slovenia, Turkey-Izmir and Ukraine)

2017

11,438

Primary CNS tumors: 100%

76

Nicolas R. Smoll [38]

Australia

2012

1372

Medulloblastoma: 100%

77

ARE HELSETH [89]

Norway

1995

10,936

Primary CNS tumors: 100%

78

Stefan L¨ONN [90]

Denmark, Finland, Norway, and Sweden

2004

43,120

Primary CNS tumors: 100%

79

Adah S. Zhang [91]

USA

2017

294,666

Brain tumor: 49.9% (glioblastoma: 44.3%, pilocytic astrocytomas: 3.7%)

80

C A STILLER [92]

UK

1994

12,509

Primary CNS tumors: 100%