Table 3 Variants detected in DCM patients who participated in our study and in-silico prediction for each mutation
From: TCAP gene is not a common cause of cardiomyopathy in Iranian patients
No. | Patient No | Nucleotide change | Amino Acid Change | Location | Zygosity | rs | Varsome | MutationTaster | Provean | SIFT | CADD | References |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | DCM1 | No mutation found | – | – | – | – | – | – | – | – | – | – |
2 | DCM2 | c.453A > C | p.Ala151 = | Exon 2 | Homo | rs1053651 | Benign | polymorphism | Neutral | Tolerated | 10.92 | [16] |
3 | DCM3 | No mutation found | – | – | – | – | – | – | – | – | – | – |
4 | DCM4 | c.453A > C | p.Ala151 = | Exon 2 | Homo | rs1053651 | Benign | polymorphism | Neutral | Tolerated | 10.92 | [16] |
5 | DCM5 | c.453A > C | p.Ala151 = | Exon 2 | Het | rs1053651 | Benign | polymorphism | Neutral | Tolerated | 10.92 | [16] |
6 | DCM6 | No mutation found | – | – | – | – | – | – | – | – | – | – |
7 | DCM7 | c.453A > C | p.Ala151 = | Exon 2 | Homo | rs1053651 | Benign | polymorphism | Neutral | Tolerated | 10.92 | [16] |
8 | DCM8 | c.453A > C | p.Ala151 = | Exon 2 | Homo | rs1053651 | Benign | polymorphism | Neutral | Tolerated | 10.92 | [16] |
9 | DCM9 | c.453A > C | p.Ala151 = | Exon 2 | Homo | rs1053651 | Benign | polymorphism | Neutral | Tolerated | 10.92 | [16] |
10 | DCM10 | c.453A > C | p.Ala151 = | Exon 2 | Homo | rs1053651 | Benign | polymorphism | Neutral | Tolerated | 10.92 | [16] |
11 | DCM11 | c.453A > C | p.Ala151 = | Exon 2 | Homo | rs1053651 | Benign | polymorphism | Neutral | Tolerated | 10.92 | [16] |
12 | DCM12 | c.453A > C | p.Ala151 = | Exon 2 | Homo | rs1053651 | Benign | polymorphism | Neutral | Tolerated | 10.92 | [16] |
13 | DCM13 | c.453A > C | p.Ala151 = | Exon 2 | Homo | rs1053651 | Benign | polymorphism | Neutral | Tolerated | 10.92 | [16] |
14 | DCM14 | c.453A > C | p.Ala151 = | Exon 2 | Homo | rs1053651 | Benign | polymorphism | Neutral | Tolerated | 10.92 | [16] |
15 | DCM15 | c.453A > C | p.Ala151 = | Exon 2 | Homo | rs1053651 | Benign | polymorphism | Neutral | Tolerated | 10.92 | [16] |
16 | DCM16 | c.453A > C | p.Ala151 = | Exon 2 | Homo | rs1053651 | Benign | polymorphism | Neutral | Tolerated | 10.92 | [16] |
17 | DCM17 | c.453A > C | p.Ala151 = | Exon 2 | Homo | rs1053651 | Benign | polymorphism | Neutral | Tolerated | 10.92 | [16] |
18 | DCM18 | No mutation found | – | – | – | – | – | – | – | – | – | – |
19 | DCM19 | No mutation found | – | – | – | – | – | – | – | – | – | – |
20 | DCM20 | No mutation found | – | – | – | – | – | – | – | – | – | – |