Fig. 1

Illustrates the inclusion criteria for selected articles in this review. Five search phases are shown up to March 30, 2022, that involved electronic medical databases like PubMed, Web of Science, MEDLINE, and Egyptian Knowledge Bank (EKB). The following queries were used to get eligible articles for this review: ((CYP3A5) AND (polymorphism)) AND (atorvastatin) for phase 1, ((CYP3A4) AND (polymorphism)) AND (atorvastatin) for phase 2, (((CYP3A5) AND (polymorphism)) AND (atorvastatin)) AND (adverse effect) for phase 3, (((CYP3A4) AND (polymorphism)) AND (atorvastatin)) AND (adverse effect) for phase 4 as well as, ((Cytochromes P450) AND (atorvastatin)) AND (Egypt) for phase 5. This review includes only 24 articles after excluding non-English language literature, books, and literature unrelated to the aim.. a. (PMs): polymorphisms, b.(ATV): atorvastatin, c.(Pub): PubMed, d. (MED): MEDLINE, e. (WOS): Web of Science, f. (EKB): Egyptian Knowledge Bank