Table 3 Main objectives of the articles that investigated CYP3A4/5 polymorphisms among the Egyptian population

1

Mutawi et al. [52]

To examine the main allelic PMs^a of CYP3A4^b, CYP3A5^b, and CYP2D6^b in the Egyptian population

2

Sharaki et al. [53]

To study the effect of CYP3A4^b rs4646437C > T and MDR1^c G2677T/A genetic variations on cyclosporine dosing in renal transplant Egyptian recipients

3

Abd El Wahab et al. [54]

To identify the frequency of CYP1A1*2C^b and CYP3A5*3^b genetic polymorphisms in Egyptians suffering acute myeloid leukemia and assess their contribution to the development of leukemia in Egyptians

4

Mendrinou et al. [55]

To determine CYP3A5*3^b allelic frequency in Egyptian renal transplanted patients and evaluate the effect of this genetic variant on tacrolimus dose requirements

5

Bedewy, El-Maghraby [56]

To identify the frequencies of CYP3A5*3^b and SLCO1B3^d (T334G) in chronic myeloid leukemia cases receiving imatinib therapy and assess the impact of these polymorphisms on the response to imatinib

6

Abo El Fotoh, et al. [57]

To determine the effect of CYP3A5*3^b and SCN1A^e c.3184 A/G polymorphisms on pharmaco-resistance in Egyptian epileptic pediatric patients