Pharmacovigilance-based drug repurposing: searching for putative drugs with hypohidrosis or anhidrosis adverse events for use against hyperhidrosis

Table 1 Algorithms used for signal detection

Algorithms	Equation	Criteria
ROR	ROR = (a/b)/(c/d)	95% CI >1, N ≥ 2
ROR	95%CI = e^{ln(ROR)±1.96(1/a+1/b+1/c+1/d)^0.5}	95% CI >1, N ≥ 2

a: number of reports containing both the suspect drug and the suspect adverse drug reaction; b: number of reports containing the suspect adverse drug reaction with other medications (except the drug of interest); c: number of reports containing the suspect drug with other adverse drug reactions (except the event of interest); d: number of reports containing other medications and other adverse drug reactions
ROR reporting odds ratio, CI confidence interval, N the number of co-occurrences

ISSN: 2047-783X