Fig. 3

Aberrant DNA methylation patterns of the ATG genes in OSA patients and those with specific phenotypes. A Mean DNA methylation levels over − 172, − 157, − 153, − 141, − 134, and − 118 CpG sites of the LC3B gene were increased in OSA patients versus PS subjects. B Mean DNA methylation levels over − 53, − 46, − 44, − 42, and − 37 CpG sites of the LC3B gene were increased in OSA patients versus PS subjects. C Mean DNA methylation levels over − 172, − 157, − 153, − 141, − 134, and − 118 CpG sites of the LC3B gene were positively correlated with apnea hyponea index. D DNA methylation levels over -153 CpG site of the LC3B gene were further increased in SDB patients with EDS versus those without EDS, and E positively correlated with Epworth Sleepiness Scale. F Mean DNA methylation levels over − 32, − 25, − 18, − 11 and − 1 CpG sites of the ATG5 gene were increased in SDB patients with morning headache versus those without headache. G Mean DNA methylation levels over − 108, − 106, − 96, − 86, − 80, − 65, and − 61 CpG sites of the ATG5 gene were increased in SDB patients with subjective memory impairment versus those with memory impairment. H Mean DNA methylation levels over − 164, − 145, − 142, and − 134 CpG sites of the p62 gene were decreased in SDB patients with nocturia versus those without nocturia. I Mean DNA methylation levels over − 105, − 101, − 99, and − 94 CpG sites of the p62 gene were decreased in SDB patients with cognitive dysfunction versus those without cognitive dysfunction