Analysis of the differential expression and prognostic relationship of DEGs in AML based on TCGA database

Table 3 Significant top up-regulated pathways participated by IGHM

Pathway	ES	NES	NOM p-val	FDR q-val	Size
1. GO_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN	0.75	2.29	< 0.001	< 0.01	138
2. GO_COMPLEMENT_ACTIVATION	0.71	2.2	< 0.001	< 0.01	157
3. GO_PHAGOCYTOSIS_RECOGNITION	0.76	2.19	< 0.001	< 0.01	72
4. GO_B_CELL_MEDIATED_IMMUNITY	0.67	2.1	< 0.001	< 0.01	206
5. GO_B_CELL_RECEPTOR_SIGNALING_PATHWAY	0.66	1.98	< 0.001	< 0.01	112
6. GO_MEMBRANE_INVAGINATION	0.64	1.95	< 0.001	< 0.01	123
7. GO_POSITIVE_REGULATION_OF_B_CELL_ACTIVATION	0.64	1.94	< 0.001	< 0.01	131

NES normalized enrichment score, NOM nominal, FDR false discovery rate
Gene sets with abs (NES) ≥ 1, NOM p-val ≤ 0.05, and FDR q-val ≤ 0.25 were considered as significant

ISSN: 2047-783X