Fig. 4

The mutational features of the IGS-high and IGS-low groups. A, the mutational landscapes of the high IGS risk subgroup and low IGS risk subgroup. B, the risk score of HCC patients with wide-type and mutation status of 5 genes with most common mutations. C, representative mutated genes in the samples of IGS-high and IGS-low subgroups. D, E, a lollipop plot illustrated the different mutation position of TP53 between the IGS-high and-low subgroup. F, the TMB in the IGS-high or -low sub-group in the pooled TCGA cohort. G, The OS of HCC patients with high IGS risk/high TMB, low IGS risk/low TMB, and high IGS risk/low TMB. H, Kaplan–Meier analysis of high IGS risk and low IGS risk in HCC patients with high TMB