Table 5 Subgroup meta-analysis of main outcomes in patients with asthma in OSA group and non-OSA group
Outcomes and subgroups | No. of studies | Population | WMD | 95%CI | I2 (%) | PH | Statistical model | PZ | Between-group P value |
|---|---|---|---|---|---|---|---|---|---|
FEV1 (%) | |||||||||
All | 13 | 1111 | − 2.29 | − 4.91, 0.33 | 75.9 |  < 0.001 | Random | 0.086 | – |
Age | |||||||||
Children | 4 | 318 | − 4.33 | − 7.82, − 0.83 | 48.6 | 0.120 | Random | 0.015 | 0.210 |
Adult | 9 | 793 | − 1.24 | − 4.56, 2.08 | 78.1 |  < 0.001 | 0.464 | – | |
Severity of OSA | |||||||||
AHI ≥ 1 or 5/h | 11 | 1013 | − 3.04 | − 5.68, − 0.40 | 77.3 |  < 0.001 | Random | 0.024 | 0.015 |
AHI ≥ 15/h | 2 | 98 | 7.69 | − 0.54, 15.93 | 0 | 0.557 | 0.067 | – | |
Severity of asthma | |||||||||
Routine | 8 | 714 | − 2.56 | − 5.83, 0.70 | 72.6 | 0.001 | Random | 0.124 | 0.863 |
Uncontrolled | 4 | 307 | − 1.34 | − 7.23, 4.54 | 86.1 |  < 0.001 | 0.655 | – | |
FVC (%) | 13 | 1111 | 0.01 | − 1.92, 1.94 | 0 | 0.573 | Fixed | 0.992 | – |
FEV1/FVC (%) | |||||||||
All | 9 | 782 | − 0.82 | − 3.08, 1.44 | 69.0 | 0.001 | Random | 0.477 | – |
Age | |||||||||
Children | 2 | 141 | − 4.75 | − 8.55, − 0.95 | 0 | 0.446 | Random | 0.014 | 0.035 |
Adult | 7 | 641 | 0.04 | − 2.28, 2.37 | 67.3 | 0.005 | 0.972 | – | |
Severity of OSA | |||||||||
AHI ≥ 1 or 5/h | 7 | 684 | − 1.65 | − 4.03, 0.74 | 72.0 | 0.002 | Random | 0.176 | 0.017 |
AHI ≥ 15/h | 2 | 98 | 4.83 | 0.05, 9.61 | 0 | 0.482 | 0.047 | – | |
Severity of asthma | |||||||||
Routine | 6 | 589 | − 1.11 | − 4.63, 2.41 | 76.6 | 0.001 | Random | 0.536 | 0.254 |
Uncontrolled | 2 | 94 | 1.01 | − 0.27, 2.30 | 0 | 0.873 | 0.123 | – | |
FEF25–75% | 3 | 179 | − 5.15 | − 12.72, 2.42 | 27.0 | 0.254 | Fixed | 0.183 | – |
ACT score | 4 | 385 | − 0.37 | − 0.74, 0.00 | 0 | 0.688 | Fixed | 0.050 | – |