The relationship between obstructive sleep apnea and asthma severity and vice versa: a systematic review and meta-analysis

Table 6 Subgroup meta-analysis of main outcomes in patients with OSA in asthma group and non-asthma group

Outcomes and subgroups	No. of studies	Population	WMD	95%CI	I² (%)	PH	Statistical model	PZ	Between-group P value
AHI (events/hour)
All	9	9540	0.47	− 1.59, 2.52	65.9	0.003	Random	0.656	–
Age
Adult	7	9434	0.72	− 1.95, 3.38	74.2	0.001	Random	0.599	0.670
Children	2	106	− 0.08	− 2.61, 2.44	0	0.703	Random	0.948	–
Severity of OSA
AHI ≥ 1 or 5/h	5	3801	0.27	− 1.97, 2.50	43.0	0.135	Random	0.686	0.912
AHI ≥ 15/h	3	5739	0.63	− 5.45, 6.71	82.1	0.004	Random	0.839	–
LSpO₂ (%)	4	6360	− 0.10	− 1.28, 1.09	47.2	0.128	Fixed	0.872	–
ODI (events/hour)	4	6310	− 0.56	− 1.68, 0.56	30.2	0.231	Fixed	0.326	–
ArI (events/hour)	3	3074	− 0.94	− 2.14, 0.26	4.6	0.351	Fixed	0.123	–
T90 (%)	3	3142	0.02	− 0.42, 0.47	0	0.536	Fixed	0.915	–
ESS score	4	9089	0.60	0.16, 1.04	0	0.678	Fixed	0.007	–

WMD; weighted mean difference, CI; confidence interval, PZ; P value for Z test, PH; P value based on Q test for between-study heterogeneity, AHI; apnea/hypopnea index, LSpO₂; lowest peripheral oxygen saturation, ODI; oxygen desaturation index, ArI; arousal index, T90%; percent sleeping time in which oxygen saturation was below 90%, ESS; Epworth Sleepiness Scale

ISSN: 2047-783X