Fig. 2

REG inhibits the growth of subcutaneous CT26 tumors in mice. A Schematic diagram of the study design including sampling details after the last REG dose. Gray triangles indicate sampling of untreated mice, black triangles of treated mice. B Fitted tumor growth curves and confidence areas based on tumor volume determinations within the exponential growth phase after treatment start. The untreated control was not included because the early sampling had an influence on the growth estimation. C Resected tumor weights after study termination. Tumors of the REG groups collected for PK analysis 1, 3, and 7 h after the last dose are omitted. Horizontal black lines represent mean values. V1 and V2 n = 6 tumors/group; REG(V1) and REG(V2) n = 9 tumors/group. D Tumor weight estimates determined as described in the statistical section of the methods. E Statistical significances derived from tumor growth model and tumor weight estimations. Significant P-values are indicated in bold. TV, tumor volume; TW, tumor weight.