Fig. 8

A. m7G score-hub gene network for the top 5 most highly regulated genes. B. Combination pattern diagram of Bleomycin and EIF4E. Yellow represents hydrogen bonding, and Amino acid residue includes ALA229, HIS228, ASN72, SER85, ARG87, ILE89, ASP71, ASP116, LYS183, and LYS138. C. Combination pattern diagram of Etoposide and EIF4E2. Yellow represents hydrogen bonding, Amino acid residue includes SER24, THR22, SER64, and THR99. D. Combination pattern diagram of Bleomycin and EIF4E3. Yellow represents hydrogen bonding, Amino acid residue includes ARG152, LEU83, ALA49, GLU93, ARG95, HIS194, and LYS192. E. Combination pattern diagram of Bleomycin and NCBP1. Yellow represents hydrogen bonding; Amino acid residue includes LYS650, ARG610, ARG646, GLN753, ASP369, LYS455, ARG458, and GLN599. F. Combination pattern diagram of Etoposide and NCBP2. Yellow represents hydrogen bonding, Amino acid residue includes ARG227, ARG104, VAL126, and ARG119. Notes: "Pocket" is a concave region made up of amino acid residues, the shape and chemistry of which allow other molecules to fit in and combine