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Table 1 GWAS sources for lung cancer and metabolic biomarkers in Europeans and East Asians

From: Genetic associations between circulating metabolic biomarkers and lung cancer in East Asians and Europeans

 

Europeans

East Asians

PMID

Sample size

Case number

Web source

PMID

Sample size

Case number

Web source

Exposures

 HDL

34887591

1,320,016

–

Global Lipids Genetics Consortium (http://csg.sph.umich.edu/willer/public/glgc-lipids2021/)

36333282

125,872

–

Korea Biobank

Array Project (https://www.koreanchip.org/kba130k)

 LDL

 TC

 Triglyceride

 FPG

33402679

151,188

–

MAGIC (https://magicinvestigators.org/downloads/)

 HbA1c

28898252

123,655

 Smokinga

30643258

518,633

–

GWAS-Catalog: GCST007327

NA

NA

NA

NA

 Alcohol drinkingb

30643258

414,343

 

GWAS-Catalog: GCST007328

NA

NA

NA

NA

 Body mass index

30124842

381,275

 

IEU OpenGWAS project: ieu-b-40 (https://gwas.mrcieu.ac.uk/datasets/ieu-b-40/)

NA

NA

NA

NA

Outcomes

 Lung cancer

28604730

85,716

29,266

GWAS-Catalog: GCST004748

34594039

178,726

4444

BioBank Japan PheWeb (https://pheweb.jp/pheno/LuC)

 LUAD

66,756

11,273

GWAS-Catalog: GCST004744

NA

NA

NA

NA

 LUSC

63,053

7426

GWAS-Catalog: GCST004750

NA

NA

NA

NA

 SCLC

24,108

2664

GWAS-Catalog: GCST004746

NA

NA

NA

NA

  1. FPG fasting plasma glucose, HbA1c glycosylated hemoglobin, HDL high-density lipoprotein cholesterol, LDL low-density lipoprotein cholesterol, TC total cholesterol, SCLC small cell lung carcinoma, LUAD lung adenocarcinoma, LUSC lung squamous cell carcinoma, NA not available
  2. asmoking status (ever vs. never smokers)
  3. bAlcohol consumption (drinks per week)