Serum vascular endothelial growth factor affects tissue fluid accumulation and is associated with deteriorating tissue perfusion and oxygenation in severe sepsis: a prospective observational study

Table 3 Correlation coefficients between NIRS parameters and intake and output, urine output, administrated fluid, serum VEGF, and serum albumin

Measures	Days	[H₂O]	[HbO₂]	[HbR]	[HbT]	StO₂
I/O^a	1	− 0.050	− 0.139	− 0.142	− 0.223	0.012
	2	− 0.013	0.036	0.036	0.041	0.014
	3	0.046	− 0.140	− 0.166	− 0.268^c	0.061
UO^a	1	− 0.084	0.233	− 0.025	0.136	0.181
	2	0.098	0.204	0.156	0.194	0.038
	3	− 0.240	0.367^b	0.136	0.297^c	0.099
IVF^a	1	0.010	− 0.143	− 0.204	− 0.259^c	0.029
	2	0.077	− 0.021	0.059	0.043	− 0.080
	3	0.179	− 0.092	− 0.025	− 0.142	− 0.042
VEGF	1	0.449^b	− 0.246^c	− 0.105	− 0.266^c	− 0.105
Albumin	1	− 0.329^b	0.130	− 0.024	0.036	0.085

Numbers in cells are Pearson’s r or Spearman’s rho correlation coefficients. NIRS: near-infrared spectroscopy; VEGF: vascular endothelial growth factor; [HbO₂]: relative tissue concentration of oxy-hemoglobin; [HbR]: relative tissue concentration of deoxy-hemoglobin; [HbT]: relative tissue concentration of total hemoglobin; StO₂: tissue hemoglobin oxygen saturation; [H₂O]: relative tissue concentration of H₂O; I/O: intake and output; UO: urine output; IVF: intravascular fluid, ^aData recorded on the day before the NIRS measurements. ^bp < 0.01; ^cp < 0.05. The actual p values have been included in Additional file 1

ISSN: 2047-783X