Table 3 Clinical and physiological characteristics of study population II
Characteristic | Total | Non-survivors | Survivors | P-value |
|---|---|---|---|---|
Number | 750 | 122 | 628 | Â |
Age (year) | 65.00 (58.00–71.00) | 68.50 (61.75–74.00) | 64.00 (58.00–71.00) | 0.000 |
Male (%) | 77.2 | 82.8 | 76.1 | 0.108 |
Body mass index | 23.63 ± 3.92 | 21.93 ± 3.85 | 23.96 ± 3.85 | 0.000 |
Smoking index (pack-yr.) | 20.00 (0.00–40.00) | 30.00 (0.00–45.00) | 20.00 (0.00–40.00) | 0.033 |
Smoking status | ||||
 Never (%) | 33.1 | 26.2 | 34.4 |  |
 Former (%) | 30.5 | 34.4 | 29.8 |  |
 Current (%) | 36.4 | 39.3 | 35.8 |  |
Comorbidity | ||||
 Hypertension (%) | 28.8 | 36.1 | 27.4 | 0.053 |
 Diabetes (%) | 6.9 | 7.4 | 6.8 | 0.833 |
 Coronary heart disease (%) | 21.6 | 28.7 | 20.2 | 0.038 |
 Pulmonary hypertension (%) | 17.1 | 33.6 | 13.9 | 0.000 |
Inhalation therapy | ||||
 SABD (%) | 2.7 | 4.1 | 2.4 | 0.444 |
 ICS/LABA (%) | 28.1 | 25.4 | 28.7 | 0.465 |
 ICS/LABA + LAMA (%) | 28.8 | 22.1 | 30.1 | 0.075 |
 LAMA (%) | 25.5 | 32.0 | 24.2 | 0.072 |
FEV1 (L) | 1.16 (0.83–1.55) | 0.88 (0.71–1.21) | 1.22 (0.87–1.62) | 0.000 |
FEV1 (% predicted) | 46.50 (32.48–63.45) | 34.35 (27.10–49.98) | 48.65 (35.15–66.18) | 0.000 |
FVC (L) | 2.51 (2.03–3.08) | 2.27 (1.80–2.65) | 2.59 (2.09–3.16) | 0.000 |
FVC (% predicted) | 79.96 ± 21.11 | 72.42 ± 20.28 | 81.43 ± 20.97 | 0.000 |
FEV1/FVC (%) | 46.99 (37.93–58.15) | 41.19 (32.83–53.72) | 48.48 (39.10–58.50) | 0.000 |
VA (L) | 4.93 ± 1.07 | 4.68 ± 0.99 | 4.98 ± 1.08 | 0.004 |
VA (% predicted) | 87.02 ± 14.55 | 82.20 ± 15.06 | 87.95 ± 14.27 | 0.000 |
DLCO (mmol/min/kPa) | 5.89 (4.41–7.39) | 4.12 (3.24–5.45) | 6.18 (4.74–7.70) | 0.000 |
DLCO (% predicted) | 75.41 ± 27.54 | 56.16 ± 24.53 | 79.15 ± 26.53 | 0.000 |
FVC/DLCO (l/mmol/min/kPa) | 0.42 (0.34–0.54) | 0.52 (0.41–0.71) | 0.41 (0.33–0.52) | 0.000 |
FVC%/DLCO% | 1.04 (0.85–1.33) | 1.26 (1.00–1.65) | 1.01 (0.83–1.26) | 0.000 |
LVEF (%) | 67.00 (62.75–71.00) | 66.00 (61.00–71.25) | 67.00 (63.00–71.00) | 0.104 |
LVFS (%) | 37.00 (34.00–41.00) | 37.00 (33.00–42.00) | 37.00 (34.00–41.00) | 0.789 |
pH | 7.43 ± 0.03 | 7.42 ± 0.04 | 7.43 ± 0.03 | 0.619 |
PaO2 (mmHg) | 71.56 ± 13.29 | 66.48 ± 14.86 | 72.55 ± 12.74 | 0.000 |
PaCO2 (mmHg) | 38.80 (35.58–42.40) | 39.95 (36.25–46.58) | 38.55 (35.40–41.70) | 0.001 |
PO2(A-a) (mmHg) | 26.90 (19.70–33.83) | 27.70 (20.85–38.70) | 26.70 (19.60–33.60) | 0.031 |
Leukocyte count (× 109/L) | 6.51 (5.18–8.25) | 6.66 (5.32–8.21) | 6.45 (5.16–8.27) | 0.650 |
Neutrophil count (× 109/L) | 4.22 (3.16–5.98) | 4.52 (3.42–6.39) | 4.16 (3.10–5.84) | 0.039 |
Platelet count (× 109/L) | 179.00 (141.00–226.00) | 166.50 (135.50–210.50) | 182.00 (143.25–227.00) | 0.083 |
Hemoglobin (g/L) | 135.86 ± 16.96 | 133.66 ± 19.93 | 136.29 ± 16.30 | 0.118 |
Albumin (g/L) | 39.80 (37.00–42.40) | 38.05 (35.60–40.80) | 40.00 (37.30–42.60) | 0.000 |
Globulin (g/L) | 24.84 ± 4.39 | 25.25 ± 4.96 | 24.75 ± 4.27 | 0.305 |
ALT (IU/L) | 17.00 (12.00–25.00) | 15.08 (11.00–22.00) | 17.00 (12.00–26.00) | 0.046 |
AST (IU/L) | 19.00 (16.00–25.00) | 20.00 (15.00–26.00) | 19.00 (16.00–24.96) | 0.663 |
DBIL (μmol/L) | 4.50 (3.36–6.00) | 4.65 (3.25–6.44) | 4.42 (3.40–5.91) | 0.295 |
IBIL (μmol/L) | 6.87 (4.79–9.43) | 6.62 (4.57–9.84) | 6.90 (4.88–9.40) | 0.587 |
Creatinine (μmol/L) | 68.93 (58.67–80.33) | 69.13 (59.37–81.77) | 68.72 (58.67–80.28) | 0.624 |
BUN (mmol/L) | 5.10 (4.11–6.19) | 5.24 (4.28–6.36) | 5.08 (4.05–6.12) | 0.135 |
Cystatin C (mg/L) | 0.99 (0.86–1.13) | 1.04 (0.89–1.21) | 0.98 (0.85–1.11) | 0.007 |
D-dimer (ng/mL) | 360.00 (210.00–620.00) | 461.50 (270.00–742.50) | 330.00 (210.00–600.00) | 0.002 |