13 total cases: 12 case reports [22, 28,29,30,31,32,33,34,35,36, 38, 39] and 1 poster abstract [40] |
Case classifications: SJS 7/13 (53.8%), SJS/TEN overlap 0/13 (0%), and 6/13 (46.2%) |
Patients ranged between 12- and 66-year-old with a female predominance of 9/13 (69.2%) |
All cases described rash presentation as photodistributed |
All cases reported ultraviolet radiation prior to rash onset |
All cases recognized a causal drug |
All patients recovered |
10 cases reported source of the UVR: 8 cases from direct sunlight, 2 cases from tanning bed |
10 cases provided images of rash extension to clothing covered skin (lack of linear demarcation, satellite lesions) |
10 cases described rash progression/worsening > 48 h (up to weeks) |
12 cases report various mucous membrane involvement, all with oral mucositis |
9 cases included biopsy findings, all consistent with SJS/TEN (4 cases reported direct immunofluorescence findings, all negative) |
7 cases reported time from UVR exposure to rash onset, all 1–3 days later |
6 cases reported Nikolsky sign findings, 5 positive |
6 cases reported palmar and plantar findings, 5 positive for rash |
No cases reported an influenza-like prodrome |