Skip to main content

Table 4 Summarized results of Photodistributed Stevens–Johnson syndrome and toxic epidermal necrolysis

From: Photodistributed Stevens–Johnson syndrome and toxic epidermal necrolysis: a systematic review and proposal for a new diagnostic classification

13 total cases: 12 case reports [22, 28,29,30,31,32,33,34,35,36, 38, 39] and 1 poster abstract [40]

Case classifications: SJS 7/13 (53.8%), SJS/TEN overlap 0/13 (0%), and 6/13 (46.2%)

Patients ranged between 12- and 66-year-old with a female predominance of 9/13 (69.2%)

All cases described rash presentation as photodistributed

All cases reported ultraviolet radiation prior to rash onset

All cases recognized a causal drug

All patients recovered

10 cases reported source of the UVR: 8 cases from direct sunlight, 2 cases from tanning bed

10 cases provided images of rash extension to clothing covered skin (lack of linear demarcation, satellite lesions)

10 cases described rash progression/worsening > 48 h (up to weeks)

12 cases report various mucous membrane involvement, all with oral mucositis

9 cases included biopsy findings, all consistent with SJS/TEN (4 cases reported direct immunofluorescence findings, all negative)

7 cases reported time from UVR exposure to rash onset, all 1–3 days later

6 cases reported Nikolsky sign findings, 5 positive

6 cases reported palmar and plantar findings, 5 positive for rash

No cases reported an influenza-like prodrome

  1. SJS Stevens-Johnson syndrome, TEN   toxic epidermal necrolysis, UVR  Ultraviolet Radiation