Table 4 Outcomes at baseline and post-intervention for patients with complete DNA methylation data
From: Exercise and epigenetic ages in older adults with myeloid malignancies
N = 20 | Statistic | Baseline | Post-intervention | Change from baseline to post-intervention | Pe |
|---|---|---|---|---|---|
Short Physical Performance Battery (SPPB)a | Mean (SD) | 9.00 (1.78) | 9.25 (2.53) | 0.25 (1.62) | 0.66 |
Median (IQR) | 9.00 (2.50) | 10.00 (3.00) | 1.00 (2.00) | ||
SPPB < 10 is considered impaired | N (%) | 11 (55.0%) | 9 (45.0%) |  | 0.69 |
Virtual SPPBa, c | Mean (SD) | 8.07 (2.94) | 8.38 (2.93) | 0.08 (2.35) | 0.73 |
Median (IQR) | 9.00 (5.00) | 9.00 (6.00) | 0.50 (1.50) | ||
Virtual SPPB < 10 is considered impaired | N (%) | 9 (75.0%) | 8 (66.7%) |  | 1 |
6-minute walk test, in metersa | Mean (SD) | 360.20 (135.93) | 334.49 (187.98) | − 25.71 (151.50) | 0.46 |
Median (IQR) | 377.04 (172.21) | 392.89 (268.99) | 7.16 (114.76) | ||
Grip strength, in kilogramsa | Mean (SD) | 25.37 (9.74) | 25.86 (9.04) | 0.49 (3.18) | 0.50 |
Median (IQR) | 25.50 (13.63) | 25.46 (13.88) | 0.58 (4.52) | ||
 < 25.8 is considered impaired in men and < 17.4 is considered impaired in women | N (%) | 10 (50.0%) | 8 (40.0%) |  | 0.63 |
Activities of Daily Living (ADL)a | Mean (SD) | 5.85 (0.49) | 5.85 (0.49) | 0.00 (0.32) | 1 |
Median (IQR) | 6.00 (0.00) | 6.00 (0.00) | 0.00 (0.00) | ||
 < 6 is considered impaired | N (%) | 2 (10.0%) | 2 (10.0%) |  | 1 |
Instrumental IADLa | Mean (SD) | 12.50 (1.88) | 12.30 (2.00) | − 0.20 (1.15) | 0.56 |
Median (IQR) | 13.00 (2.00) | 13.00 (4.00) | 0.00 (0.00) | ||
 < 14 is considered impaired | N (%) | 2 (10.0%) | 2 (10.0%) |  | 1 |
Brief Fatigue Inventoryb | Mean (SD) | 28.45 (20.25) | 23.85 (19.60) | − 4.60 (16.86) | 0.24 |
Median (IQR) | 25.00 (27.00) | 15.50 (39.00) | − 2.00 (23.50) | ||
Center for Epidemiologic Studies Depressionb | Mean (SD) | 12.10 (7.71) | 11.50 (8.14) | − 0.60 (6.34) | 0.68 |
Median (IQR) | 11.50 (13.50) | 10.50 (9.50) | 0.00 (6.50) | ||
 > 15 is considered impaired | N (%) | 6 (30.0%) | 4 (20.0%) |  | 0.63 |
Functional Assessment of Cancer Therapy-Leukemiaa | Mean (SD) | 125.20 (21.67) | 127.20 (24.02) | 2.00 (13.28) | 0.51 |
Median (IQR) | 126.92 (25.83) | 133.50 (28.17) | 1.83 (20.25) | ||
Montreal Cognitive Assessment (MOCA)a,d | Mean (SD) | 25.29 (3.48) | 25.76 (3.05) | 0.47 (3.00) | 0.53 |
Median (IQR) | 26.00 (5.00) | 27.00 (3.00) | 0.00 (3.00) | ||
 < 26 is considered impaired | N (%) | 7 (41.2%) | 6 (35.3%) |  | 1.00 |