Table 1 Detailed information on used studies
Lifestyle factor | Unit | Participants included in analysis | Adjustments | IVs | Sample overlap (%) | PubMed ID |
|---|---|---|---|---|---|---|
Smoking initiation | SD in prevalence of smoking initiation | 1,232,091 European-descent individuals | Age, sex, and the first ten genetic principal components | 11 | 2.5 | 30643251 |
Alcohol drinking | SD increase of log-transformed alcoholic drinks/week | 941,280 European-descent individuals | Age, sex, and the first ten genetic principal components | 6 | 3.3 | 30643251 |
Coffee consumption | 50% change | 375,833 European-descent individuals | Age, sex, body mass index, total energy, proportion of typical food intake, and 20 genetic principal components | 32 | 6.2 | 31046077 |
Vigorous physical activity | ≥ 3 versus 0 day/week | 98,060 cases and 162,995 controls of European descent | Age, sex, genotyping chip, first ten genomic principal components, and center | 15 | 11.8 | 29899525 |
Heavy physical work | Never or rarely; sometimes; usually; always; do not know | 288,477 European-descent individuals | – | 22 | 9.6 | – |
Metabolic factor | ||||||
 Body mass index | SD | 224,459 European-descent individuals | Age, sex, genotyping chip | 42 | 2.9 | 25673412 |
 WHR | SD | 224,459 European-descent individuals | Age, sex, genotyping chip | 25 | 3.1 | 25673412 |
 WHR adjusted for BMI | SD | 224,459 European-descent individuals | Age, sex, genotyping chip | 34 | 3.3 | 25673412 |
 Type 2 diabetes | One-unit in log-transformed odds | 898,130 European-descent individuals | Age, sex, and the first ten genetic principal components | 231 | 0.0 | 30297969 |
 Systolic blood pressure | 10 mm Hg | Up to 1,006,863 European-descent individuals | Age, sex, BMI, genotyping chips | 444 | 3.4 | 30224653 |
 Diastolic blood pressure | 10 mm Hg | Up to 1,006,863 European-descent individuals | Age, sex, BMI, genotyping chips | 448 | 3.6 | 30224653 |
 LDL-C | SD | 188,577 European-ancestry individuals | Age, sex, BMI, genotyping chips | 96 | 7.8 | 24097068 |
 HDL-C | SD | 188,577 European-ancestry individuals | Age, sex, BMI, genotyping chips | 122 | 7.8 | 24097068 |
 Triglycerides | SD | 188,577 European-ancestry individuals | Age, sex, BMI, genotyping chips | 71 | 6.9 | 24097068 |
Socioeconomic status | ||||||
 Education attainment | SD change of education years | 765,283 European-ancestry individuals | Age, sex, genotyping chip | 404 | 1.3 | 35361970 |