Lifestyle factors, metabolic factors and socioeconomic status for pelvic organ prolapse: a Mendelian randomization study

Liu, Hailang; Wu, Wei; Xiang, Wei; Yuan, Jingdong

doi:10.1186/s40001-023-01148-w

Table 2 Associations of genetically predicted risk factors with pelvic organ prolapse in MR sensitivity analyses

From: Lifestyle factors, metabolic factors and socioeconomic status for pelvic organ prolapse: a Mendelian randomization study

	SNPs	Cochrane’s Q	F-statistic	Weighted Median		MR-Egger		MR-PRESSO		P_pleiotropy	P_{distortion test}
	SNPs	Cochrane’s Q	F-statistic	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P	P_pleiotropy	P_{distortion test}
UK Biobank
Lifestyle factor
Smoking initiation	11	178.50	705	1.002 (0.986–1.018)	0.756	1.011 (0.929–1.102)	0.795	1.005 (0.991–1.020)	0.490	0.886	NA
Alcohol drinking	6	1.83	429	1.020 (0.995–1.046)	0.116	1.024 (0.990–1.059)	0.298	1.015 (0.992–1.038)	0.196	0.552	NA
Coffee consumption	32	53.09	38	1.007 (0.983–1.031)	0.588	0.982 (0.944–1.023)	0.392	1.002 (0.983–1.023)	0.804	0.262	NA
Vigorous physical activity	15	19.77	335	0.994 (0.985–1.003)	0.169	0.982 (0.967–0.997)	0.036	0.995 (0.988–1.003)	0.214	0.074	NA
Heavy physical work	22	26.44	39	1.014 (0.992–1.036)	0.219	1.004 (0.956–1.055)	0.866	1.014 (0.997–1.032)	0.129	0.679	NA
Metabolic factor
Body mass index	42	51.37	113	1.006 (0.997–1.015)	0.18	1.015 (0.997–1.034)	0.112	1.007 (0.999–1.013)	0.058	0.329	NA
WHR	25	37.71	117	1.018 (1.006–1.029)	0.003	1.05 (1.001–1.102)	0.058	1.019 (1.009–1.029)	6.15 × 10^–5	0.222	NA
WHR adjusted for BMI	34	48.73	139	1.014 (1.004–1.023)	0.003	1.032 (1.003–1.062)	0.036	1.017 (1.009–1.024)	7.75 × 10^–6	0.284	0.677
Type 2 diabetes	231	285.31	509	1.001 (0.997–1.003)	0.643	1.00 (0.996–1.004)	0.836	1.001 (0.999–1.003)	0.059	0.499	NA
Systolic blood pressure	444	642.88	186	1.00 (0.999–1.0002)	0.409	0.999 (0.998–1.00)	0.049	1.00 (0.999–1.0001)	0.351	0.094	0.844
Diastolic blood pressure	448	690.40	171	1.00 (0.999–1.0004)	0.635	0.999 (0.998–1.0004)	0.206	1.00 (0.999–1.0005)	0.745	0.159	0.887
LDL-C	96	134.49	249	0.998 (0.995–1.003)	0.611	0.999 (0.994–1.004)	0.711	0.999 (0.997–1.003)	0.796	0.788	0.09
HDL-C	122	166.64	162	0.998 (0.993–1.003)	0.401	1.003 (0.997–1.009)	0.28	0.997 (0.994–1.001)	0.146	0.022	0.828
Triglycerides	71	107.55	195	0.998 (0.993–1.004)	0.539	0.998 (0.991–1.005)	0.565	1.001 (0.997–1.005)	0.573	0.239	0.956
Socioeconomic status
Education attainment	404	475.25	62	0.985 (0.978–0.992)	5.27 × 10^–5	0.996 (0.977–1.016)	0.685	0.986 (0.981–0.992)	1.14 × 10^–7	0.324	0.801
FinnGen consortium
Lifestyle factor
Smoking initiation	11	204.75	705	1.04 (0.74–1.45)	0.824	0.79 (0.22–2.85)	0.733	1.01 (0.78–1.31)	0.939	0.715	NA
Alcohol drinking	6	5.08	429	1.09 (0.50–2.41)	0.817	0.29 (0.06–1.35)	0.189	0.89 (0.48–1.65)	0.733	0.193	NA
Coffee consumption	32	29.50	38	0.63 (0.39–1.02)	0.061	0.63 (0.31–1.27)	0.202	0.67 (0.47–0.96)	0.03	0.818	NA
Vigorous physical activity	14	22.94	335	0.89 (0.75–1.07)	0.233	1.02 (0.71–1.47)	0.925	0.83 (0.69–0.98)	0.043	0.229	NA
Heavy physical work	22	28.17	39	0.95 (0.57–1.58)	0.837	1.05 (0.39–2.78)	0.928	1.12 (0.75–1.68)	0.588	0.882	NA
Metabolic factor
Body mass index	42	57.20	113	1.19 (0.97–1.45)	0.097	1.18 (0.75–1.87)	0.477	1.04 (0.88–1.22)	0.316	0.545	0.697
WHR	25	30.07	117	1.43 (1.11–1.84)	0.006	6.07 (2.50–14.74)	0.001	1.31 (1.08–1.60)	0.006	0.002	NA
WHR adjusted for BMI	34	76.76	139	1.24 (1.01–1.53)	0.039	1.37 (0.60–3.14)	0.463	1.31 (1.06–1.62)	0.023	0.913	0.115
Type 2 diabetes	231	290.77	509	1.01 (0.96–1.07)	0.612	1.06 (0.97–1.15)	0.227	1.03 (0.99–1.07)	0.092	0.595	0.922
Systolic blood pressure	444	807.48	186	1.00 (0.99–1.01)	0.438	0.99 (0.98–1.01)	0.396	1.00 (0.99–1.01)	0.978	0.346	0.019
Diastolic blood pressure	448	764.48	171	0.99 (0.98–1.01)	0.745	1.00 (0.98–1.03)	0.81	1.00 (0.99–1.01)	0.578	0.934	0.903
LDL-C	96	141.92	249	1.03 (0.94–1.13)	0.551	1.01 (0.91–1.12)	0.796	0.98 (0.91–1.05)	0.539	0.373	NA
HDL-C	122	174.50	162	0.85 (0.76–0.95)	0.003	0.85 (0.74–0.98)	0.038	0.91 (0.84–0.98)	0.049	0.333	0.51
Triglycerides	71	162.83	195	1.11 (0.96–1.28)	0.148	1.10 (0.90–1.35)	0.348	1.11 (0.98–1.26)	0.11	0.938	0.763
Socioeconomic status
Education attainment	404	488.59	62	0.76 (0.64–0.91)	0.002	0.56 (0.37–0.85)	0.007	0.81 (0.71–0.91)	0.001	0.074	NA

BMI, body mass index; CI, confidence interval; OR, odds ratio; SNP, single nucleotide polymorphism; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; MR, Mendelian randomization; MR-PRESSO, MR-pleiotropy residual sum and outlier; NA, not available. WHR, waist-to-hip ratio

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