Association of statin use and increase in lipoprotein(a): a real-world database research

Table 2 Association between treatment with statin-based drugs versus non-statin use and the change of the Lp(a)

Item	Non-statin use (n = 21,083)	Statin use (n = 21,083)	HR(CI95%)
Item	Non-statin use (n = 21,083)	Statin use (n = 21,083)	Model 1^*	Model 2^@
Primary outcome
Lp(a) decrease (FU^#)	8868(42.06%)	2956(14.02%)	1.43(1.40, 1.47)^&	1.47(1.43, 1.50)^&
Lp(a) increase (FU^#)	12,215(57.94%)	18,127(85.98%)
Lp(a) decrease (FU^$)	14,204(67.37%)	8477(40.21%)	1.77(1.72, 1.82)^&	1.40(1.36, 1.43)^&
Lp(a) increase (FU^$)	6879(32.63%)	12,606(59.79)

^*Changes in Lp(a) between statin use and non-statin use patients were compared using a conventional proportional hazard model
^@Adjusted the proportional hazard model by Age, CRP, Follow-up(months), LDL-C, Comorbidity (FE), HDL-C, APO-A, APO-B,and the change of LDL-C
^#The change of Lp(a) was calculated using linear mixed modeling. The outcome is Lp(a) decrease or Lp(a) increase. FU: Follow-up
^$The change of Lp(a) was calculated using linear mixed modeling. The outcome is Lp(a) decrease or Lp(a) increase if the increased level of Lp(a) increases 50 mg/L. FU: Follow-up
^&p < 0.05

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