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Table 2 Univariate and multivariate Cox proportional hazard analysis of factors associated with DFS and OS

From: Dynamic change of the systemic immune inflammation index is a risk factor for patients with oropharyngeal cancer: a case control study and an additional HPV-status subgroup analysis

Variables

DFS

OS

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

HR (95% CI)

p-value

HR (95% CI)

p-value

HR (95% CI)

p-value

HR (95% CI)

p-value

Dynamic SII

1.90 (1.20–3.03)

0.007*

1.77 (1.10–2.85)

0.019*

2.11 (1.20–3.69)

0.009*

2.01 (1.13–3.59)

0.018*

Age

0.99 (0.97–1.01)

0.349

  

1.01 (0.99–1.03)

0.400

  

Gender

1.28 (0.76–2.17)

0.351

  

0.93 (0.52–1.6)

0.808

  

Tumor site

 Tonsil$

 

0.103

   

0.320

  

 Pharyngolaryngeal fossa

0.75 (0.10–5.51)

0.779

  

0.00 (0.00–0.00)

0.978

  

 Soft palate

1.41 (0.55–3.63)

0.474

  

1.72 (0.64–4.60)

0.282

  

 Tongue base

1.88 (1.19–2.98)

0.007*

2.06 (1.26–3.37)

0.004*

1.80 (1.02–3.18)

0.043*

1.99 (1.12–3.55)

0.019*

 Uvula

1.93 (0.26–14.21)

0.518

  

2.83 (0.38–21.18)

0.312

  

Stage

2.09 (1.00–4.34)

0.049*

1.93 (0.86–4.34)

0.039*

1.40 (0.63–3.08)

0.410

  

T stage

1.62 (1.05–2.51)

0.031*

1.13 (0.69–2.51)

0.113

1.45 (0.86–2.43)

0.163

  

N stage

1.12 (0.69–1.80)

0.645

  

1.97 (0.57–2.67)

0.922

  

Positive margin

1.95 (0.75–2.70)

0.650

  

1.05 (0.79–1.39)

0.735

  

Extranodal extension

1.91 (0.37–2.51)

0.435

  

1.00 (0.75–1.33)

0.990

  

Muscular or capsule invasion

1.03 (0.92–1.20)

0.556

  

1.08 (0.71–1.35)

0.894

  

Nerve invasion

1.25 (0.30–5.13)

0.760

  

1.27 (0.11–5.59)

0.794

  

Vascular invasion

1.84 (0.79–4.28)

0.157

  

4.07 (1.69–9.79)

0.002*

4.22 (1.69–10.49)

0.002*

Cigarette smoking

1.42 (0.90–2.24)

0.136

  

1.19 (0.69–2.05)

0.524

  

Alcohol drinking

1.58 (1.01–2.49)

0.046*

1.66 (1.03–2.66)

0.037*

1.31 (0.77–2.22)

0.316

  
  1. B, coefficient; SE, standard error; Wald, statistic; HR, hazard ratio; CI, confidence interval
  2. *Significant different
  3. $Dummy argument