Table 1 Baseline characteristics
All (N = 22) | HCM (N = 16) | HOCM (N = 8) | HNCM (N = 8) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Parameters | HCM N = 16 | NC N = 6 | P | HOCM N = 8 | HNCM N = 8 | P | Gene ( +) N = 4 | Gene (−) N = 4 | P | Gene ( +) N = 4 | Gene (−) N = 4 | P |
Age, years | 43.19 (10.18) | 35.67 (12.99) | 0.167 | 43.50 (8.72) | 42.88 (12.08) | 0.907 | 42.50 (7.33) | 44.50 (11.00) | 0.772 | 38.25 (10.40) | 47.50 (13.23) | 0.314 |
Sex (N, %) | 13 (81.25) | 4 (66.67) | 0.585 | 6 (75.00) | 7 (87.50) |  > 0.999 | 3 (0.75) | 4 (1.00) |  > 0.999 | 2 (0.50) | 4 (1.00) | 0.429 |
BMI, kg/m2 | 25.89 (2.71) | 22.80 (2.06) | 0.020 | 25.19 (2.53) | 26.59 (2.86) | 0.318 | 24.02 (2.74) | 26.36 (1.95) | 0.213 | 24.61 (1.65) | 28.57 (2.43) | 0.035 |
SBP, mmHg | 123.69 (15.91) | 127.17 (10.21) | 0.625 | 116.38 (17.14) | 131 (11.25) | 0.063 | 107.75 (16.92) | 125.00 (14.17) | 0.169 | 128.25 (16.26) | 133.75 (3.30) | 0.532 |
DBP, mmHg | 73.88 (13.10) | 78.50 (6.75) | 0.424 | 68 (16.33) | 79.75 (4.74) | 0.071 | 63.25 (5.85) | 72.75 (22.97) | 0.453 | 78.25 (5.56) | 81.25 (3.95) | 0.413 |
MWT, mm | 24.69 (5.69) | 8.17 (0.98) |  < 0.001 | 26.00 (5.81) | 23.38 (5.63) | 0.374 | 25.50 (7.77) | 26.50 (4.20) | 0.828 | 24.75 (5.50) | 22.00 (6.22) | 0.532 |
LVOTGrest, mmHg | 21.00 (4.75, 72.00) | 3.00 (2.75, 3.25) | 0.001 | 24.00 (22.00, 30.75) | 5.50 (4.00, 12.00) | 0.001 | 33.50 (28.75, 66.00) | 86.50 (72.00, 102.50) | 0.081 | 5.50 (4.00, 12.25) | 6.50 (3.25, 12.00) | 0.767 |
LVOTGmax, mmHg | 49.50 (13.48, 120.75) | – |  | 119.50 (96.75, 126.78) | 13.95 (8.15, 19.25) | 0.001 | 108.00 (78.00, 120.75) | 125.85 (103.00, 135.43) | 0.149 | 13.95 (9.25, 18.73) | 12.80 (8.15, 25.25) | 0.885 |
LAD, mm | 41.88 (6.33) | 33.33 (1.03) |  < 0.001 | 43.75 (7.11) | 40.00 (5.24) | 0.249 | 48.00 (5.35) | 39.50 (6.40) | 0.088 | 39.00 (4.97) | 41.00 (6.06) | 0.628 |
RAD, mm | 32.31 (4.44) | 30.83 (0.98) | 0.226 | 32.50 (4.78) | 32.13 (4.39) | 0.873 | 33.75 (4.35) | 31.25 (5.50) | 0.503 | 31.25 (5.19) | 33.00 (4.00) | 0.612 |
EDV, ml | 78.81 (15.01) | 71.50 (2.95) | 0.080 | 78.13 (10.59) | 79.50 (19.22) | 0.862 | 77.75 (12.42) | 78.50 (10.34) | 0.929 | 75.00 (26.99) | 84.00 (8.91) | 0.550 |
ESV, ml | 31.31 (9.66) | 29.33 (1.86) | 0.445 | 31.00 (6.91) | 31.63 (12.33) | 0.902 | 30.00 (5.23) | 32.00 (9.02) | 0.714 | 29.50 (15.84) | 33.75 (9.58) | 0.662 |
E/A | 0.85 (0.29) | 1.19 (0.20) | 0.019 | 0.81 (0.27) | 0.89 (0.33) | 0.623 | 0.93 (0.30) | 0.70 (0.20) | 0.256 | 0.73 (0.14) | 1.05 (0.41) | 0.220 |
E/e’ | 12.75 (10.55, 15.50) | 6.90 (6.30, 7.29) | 0.002 | 15.71 (6.87) | 11.88 (2.28) | 0.157 | 14.08 (3.48) | 17.34 (9.54) | 0.544 | 11.45 (3.10) | 12.30 (1.44) | 0.637 |
LVEF (%) | 60.81 (5.37) | 58.67 (1.97) | 0.185 | 60.63 (4.75) | 61.00 (6.26) | 0.895 | 61.50 (2.89) | 59.75 (6.50) | 0.640 | 62.00 (6.33) | 60.00 (6.98) | 0.686 |