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Table 2 Primary and secondary outcomes of patients in DIRECT-MT

From: Impact of anesthesia modalities on functional outcome of mechanical thrombectomy in patients with acute ischemic stroke: a subgroup analysis of DIRECT-MT trial

 

Non-general anesthesia

General anesthesia

P value

Clinical outcomes

   

mRS score at 90 days, median(IQR)

3(2–5)

4(2–5)

0.10

 mRS of 0–1 at 90 days, n (%)

   

  0–1

100(23.31)

50(24.15)

0.81

  2–6

329(76.69)

157(75.85)

 

 mRS of 0–2 at 90 days, n (%)

   

  0–2

166(38.69)

68(32.85)

0.15

  3–6

263(61.31)

139(67.15)

 

 mRS of 0–3 at 90 days, n (%)

   

  0–3

241(56.18)

98(47.34)

0.04

  4–6

188(43.82)

109(52.66)

 

  NIHSS score after 24 h, median (IQR)

11(4–19)

15(6–26)

0.001

  NIHSS score at 5–7 days or discharge, median (IQR)

6.5(2–16)

10(2–23)

0.046

  Barthel Index at 90 days, n (%), 95 OR 100

215(50.12)

81(39.13)

0.009

Procedural outcomes

   

 eTICI score assessed on final angiogram, n (%)

   

  ≥ 2b

340(81.34)

169(83.25)

0.56

  < 2b

78(18.66)

34(16.75)

 

 Total attempts of thrombectomy, median (IQR)

2(1–3)

2(1–3)

0.29

 Outcome lesion volume on CT, median (IQR)a

36.1(9.44,106.40)

38.1(11.33,103.62)

0.98

Safety outcomes

   

 Death, n (%)

73(17.02)

45(21.74)

0.15

 Symptomatic intracranial hemorrhage, n (%)b

25(5.83)

8(3.86)

0.30

 Asymptomatic intracranial hemorrhage, n (%)

151(35.20)

77(37.20)

0.62

 Infarction in new territory at 5–7 days, n (%)

17(3.96)

3(1.45)

0.089

Technical complications

   

 Any procedural complications, n (%)

68(15.85)

27(13.04)

0.35

 Vessel dissection, n (%)

8(1.86)

5(2.42)

0.87

 Contrast extravasation, n (%) c

14(3.26)

2(0.97)

0.08

 Embolization into a new territory, n (%)d

45(10.49)

20(9.66)

0.75

  1. mRS modified Rankin Scale; IQR interquartile range; eTICI extended Thrombolysis in Cerebral Infarction; CT computed tomography
  2. aThe volume was calculated by the StrokeViewer software at Nicolab in Netherlands
  3. bThe definition of symptomatic intracranial hemorrhage was according to the Heidelberg criteria
  4. cContrast extravasation was defined as contrast leakage on dynamic angiography confirmed by imaging core lab
  5. dThe definition of embolization in a new territory was defined as the angiographic occlusion in a previously unaffected vascular territory observed on the angiogram