Table 5 Suggested criteria for the diagnosis of ASIA
Major Criteria | Minor Criteria |
|---|---|
Exposure to an external stimuli (Infection, vaccine, silicone, adjuvant) prior to clinical manifestations | The appearance of autoantibodies or antibodies directed at the suspected adjuvant |
The appearance of’typical’ clinical manifestations: Myalgia, Myositis or muscle weakness Arthralgia and/or arthritis Chronic fatigue, un-refreshing sleep or sleep disturbances Neurological manifestations (especially associated with demyelination) Cognitive impairment, memory loss Pyrexia, dry mouth | Other clinical manifestations |
Removal of inciting agent induces improvement | Specific HLA (i.e. HLA DRB1, HLA DQB1) |
Typical biopsy of involved organs | Evolvement of an autoimmune disease |