Variant rs17619600 in the gene encoding serotonin receptor 2B (HTR2B) increases the risk of gestational diabetes mellitus: a case–control study

Table 2 Genotype frequencies of single nucleotide polymorphisms in HTR2B according to status of gestational diabetes mellitus

SNPs	Without GDM	With GDM	OR (CI 95%)	P value
HTR2B (N)	443	453
rs765458
AA	0.248	0.239	0.90 (0.64–1.27)	0.55 (RD)
AG	0.542	0.518	1.02 (0.82–1.27)	0.82 (CD)
GG	0.210	0.243
MAF	0.481	0.502
rs10187149
AA	0.324	0.338
AC	0.509	0.498	0.94 (0.77–1.45)	0.70 (RD)
CC	0.167	0.164	0.92 (0.74–1.14)	0.46 (CD)
MAF	0.422	0.413
rs10194776
TT	0.277	0.279
TC	0.526	0.495	0.99 (0.79–1.52)	0.57 (RD)
CC	0.197	0.226	0.96 (0.78–1.19)	0.74 (CD)
MAF	0.479	0.473
rs17619600
TT	0.839	0.614	2.32 (1.61–3.37)	< 0.0001 (RD)
TC	0.149	0.329	2.15 (1.53–3.09)	< 0.0001 (CD)
CC	0.012	0.057
MAF	0.087	0.223

Analyses were performed in the rare dominant (RD) and in the co-dominant (CD) models after adjustment for age, pre-gestational body mass index and weight gain by binary logistic regression analysis
CI confidence interval; GDM gestational diabetes mellitus; MAF minor allele frequency; OR odds ratio; SNPs single nucleotide polymorphisms

ISSN: 2047-783X