Fig. 4

Mutation genes, location, predicted partners, functional pathway, tumor immune microenvironment, tumor heterogeneity and stemness of P4HB. a Mutation landscape of PCa patients in the TCGA database; b mutation genes between high and low P4HB expression; c predicted sublocation of P4HB; d reported pathway of P4HB in the HPA database; e predicted interaction genes of P4HB using GeneMANIA database; f predicted functional partners of P4HB using STRING database; g functional pathways between high and low P4HB expression using GSVA methods; h bubble diagram showing the correlations of P4HB expression with tumor heterogeneity and stemness; i bubble diagram showing the correlations of P4HB expression with tumor microenvironment scores; j heatmap showing the relationship between P4HB expression and tumor-infiltrating cells; k scatter diagram showing the relationship between P4HB expression and TIDE score; l heatmap showing the relationship between P4HB expression and immunostimulators; m heatmap showing the relationship between P4HB expression and immunoinhibitors; n scatter diagram showing the relationship between P4HB expression and PVRL2. TIDE tumor immune dysfunction and exclusion