Table 2 Summary of extracted outcome data and pooled analysis
Study | LM ORR (%) | Â | LM DCR (%) | Â | PFS (moths) | Â | OS (moths) | 1-y OS rate (%) | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Median | 95% CI | Median | 95% CI | Median | 95% CI | Median | 95% CI | |||||
Yang 2019 | 62 (23/37) | 45–78 |  | 95 (35/37) | 82–99 |  | 8.6 | 5.4–13.7 |  | 11.0 | 8.0–18.0 | 48.8 |
Lee 2020 | NA | NA |  | NA | NA |  | NA | NA |  | 17.0 | 15.1–18.9 | 61.8 |
Ahn 2020 | 55 (12/22) | 32–76 |  | 91 (20/22) | NA |  | 11.1 | 4.6-NR |  | 18.8 | 6.3-NR | 63.6 |
Park 2020 | 12.5 (5/40) | NA | Â | 92.5 (37/40) | NA | Â | 8.0 | 7.2-NR | Â | 13.3 | 9.1-NR | 55.0 |
Nanjo 2017 | NA) | NA | Â | NA | NA | Â | NA | NA | Â | NR | NA | NA |
Zheng 2020 | 38.2 (13/34) | NA |  | NA | NA |  | 15.6a | 4.0–17.2a |  | NA | NA | NA |
|  |  |  | 7.0b | 4.0–10.0b |  | |||||||
Saboundji 2018 | NA | NA |  | NA | NA |  | 17.3 | 2.7–20.8 |  | 18.0 | 4.4–23.8 | 65.0 |
Reungwetwattana 2018 | 80 (4/5) | NA | Â | 100 (5/5) | NA | Â | NA | NA | Â | NA | NA | NA |
Akazawa 2019 | 33.3 (2/6) | NA | Â | 83.3 (5/6) | NA | Â | 3.7 | NA | Â | NR | NA | NA |
Ahn 2019 | 25 (10/40) | NA | Â | 90 (36/40) | NA | Â | NA | NA | Â | 13.2 | NA | NA |
Andrew 2020 | NA | NA |  | NA | NA |  | 5.8 | 1.7–9.0 |  | NA | NA | NA |
Meta-analysis | 42 | 24–59 |  | 90 | 85–94 |  | NA | NA |  | NA | NA | 59 (53–65) |