Table 3 Meta-analysis of common adverse events
Adverse events | No. of studies | Any grade |  |  ≥ Grade 3 | ||||
|---|---|---|---|---|---|---|---|---|
Patients | Rates % (95% CI) | Heterogenicity (I2) (%) | Â | Patients | Rates % (95% CI) | Heterogenicity (I2) (%) | ||
Rash | 3 | 45/94 | 48 (25–81) | 88 |  | 1/94 | 1 (0–3) | 0 |
Diarrhea | 3 | 49/103 | 48 (29–61) | 66 |  | 3/103 | 3 (0–5) | 11 |
Paronychia | 3 | 33/94 | 35 (25–44) | 0 |  | 0/94 | 0 (0–2) | 0 |
Decrease Appetite | 3 | 38/103 | 37 (13–57) | 84 |  | 3/103 | 3 (0–5) | 17 |
Dry skin | 3 | 28/103 | 27 (18–35) | 0 |  | 0/103 | 0 (0–2) | 0 |
Pneumonia | 3 | 6/94 | 6 (0–8) | 6 |  | 4/94 | 4 (0–7) | 0 |
Nausea | 2 | 22/81 | 27 (8–45) | 75 |  | 1/81 | 1 (0–4) | 0 |
Stomatitis | 2 | 11/81 | 14 (6–21) | 0 |  | 1/81 | 1 (0–4) | 0 |