Fig. 4

Genomic alterations, stemness, and drug sensitivity features across cuproptosis subtypes in TCGA cohort. A–C OncoPrint plots show the top 30 genes with mutation frequencies across cuproptosis subtypes. Row denotes mutated genes, and column denotes ccRCC samples. The left bar exhibits the mutation percentage, and the top bar exhibits the total number of mutations. Clinicopathological features are displayed at the bottom. D, E Differences in SNV neoantigens and TMB between cuproptosis subtypes. F OncoPrint plot exhibits the top 5 copy number amplifications and deletions across cuproptosis subtypes. Row denotes SCNA, and column denotes ccRCC samples. The left bar displays the percentage of SCNA, and the right bar displays the total number of SCNA. G–K Differences in SCNA, CTA score, homologous recombination defects, intratumor heterogeneity, and mRNAsi between cuproptosis subtypes. L–N Differences in IC50 of GDSC-derived compounds between cuproptosis subtypes. For violin plots, each point denotes a sample; the center line denotes the median, and the upper and lower lines denote the upper and lower quartiles. For asterisks, ns: p > 0.05; *p < 0.05; **p < 0.01; ***p < 0.001