Fig. 8

Associations of Cuscore with immunogenomic features, oncogenic hallmark pathways, post-transcriptional mechanisms in TCGA cohort. A–D Spearman correlation analysis of Cuscore with aneuploidy score, CTA score, homologous recombination defects, and intratumor heterogeneity. E Relative abundance of 22 tumor-infiltrating immune cell types and two stromal components in ccRCC samples with low to high Cuscore. Colors from blue to red correspond to low to high cell abundance. F Transcriptome profiling of immune checkpoints across ccRCC samples with low to high Cuscore. Colors from blue to red correspond to low to high expression of immune checkpoints. G The fGSEA compares the activity of the hallmark pathways between low and high Cuscore groups. H Differences in miRNA-targeted pathways between low and high Cuscore samples. Red line denotes a down-regulated miRNA in high Cuscore group, and cyan line denotes an up-regulated miRNA. Red dot represents a miRNA-targeted mRNA up-regulated in high Cuscore group, and cyan dot represents a down-regulated miRNA-targeted mRNA. Circle corresponds to a pathway enriched by targeted mRNAs. For asterisks, ***p < 0.001