Fig. 9

Recognition of Cuscore-relevant compounds and druggable targets. A Associations of Cuscore with estimated IC50 values of compounds from GDSC. B Pathways underlying GDSC-derived compounds. C Associations of Cuscore with estimated AUC values of compounds from CTRP (left), and comparison of AUC values of compounds between low and high Cuscore groups (right). D Spearman correlation analysis on Cuscore and estimated AUC values of PRISM-derived compounds (left), and comparison of AUC values of compounds between low and high Cuscore groups (right). E Relationships of Cuscore with protein expression of druggable targets. Red dot denotes a significant negative correlation (correlation coefficient < −0.5 and p < 0.05). F Relationships of Cuscore with CERES score of druggable targets. Blue dot denotes a significant negative correlation (correlation coefficient > 0.75 and p < 0.05)