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Table 2 Serum variables of the study groups at the baseline and the end of intervention. The groups were compared using general linear model (GLM) with generalized estimating equations (GEE) approach

From: Effect of two vitamin D repletion protocols on 24-h urine calcium in patients with recurrent calcium kidney stones and vitamin D deficiency: a randomized clinical trial

 

Study groups

Time effect

Group effect

2000 IU/daily

50,000 IU/weekly

β (95% CI)

p- value

β (95% CI)

p- value

Before

After

Before

After

25(OH)D (ng/mL)

16.24 (3.05)

24.82 (7.75)

16.09 (3.50)

31.88 (8.85)

12.53 (10.26, 14.80)

 < 0.001***

3.46 (1.21, 5.70)

0.003**

PTH (pg/mL)

56.23 (16.93)

48.84 (16.15)

54.35 (19.22)

47.37 (15.80)

− 7.16 (− 10.23, − 4.08)

 < 0.001***

3.98 (− 9.48, 6.13)

0.675

Calcium (mg/dl)

9.31 (0.32)

9.51 (0.48)

9.34 (0.45)

9.38 (0.42)

0.11 (− 0.02, 0.25)

0.112

− 0.05 (-.20, 0.10)

0.516

Phosphate (mg/dl)

3.25 (0.52)

3.47 (0.74)

3.35 (0.54)

3.56 (0.49)

0.21 (0.02, 0.41)

0.025*

0.10 (− 0.10, 0.30)

0.345

Creatinine (mg/dl)

1.12 (0.24)

1.07 (0.16)

1.10 (0.20)

1.12 (0.18)

− 0.009 (− 0.05, 0.03)

0.690

0.01 (− 0.07, 0.10)

0.743

  1. Before and after values in the table are shown as mean (standard deviation)
  2. CI, confidence interval; 25(OH)D, 25-hydroxyvitamin D; PTH, parathyroid hormone; BUN, Blood urea nitrogen
  3. *p < 0.05; **p < 0.01; ***p < 0.001. Bold values emphasize statistical significance
  4. Regression coefficient (β) were reported along with 95% confidence interval. The β (regression coefficient) signifies how much the mean of a dependent variable (for example the level of serum parathyroid hormone) changes when the participants received loading vitamin D repletion therapy (50,000 IU cholecalciferol/oral/ weekly) compared with the maintenance vitamin D repletion protocol (2000 IU cholecalciferol/oral/daily)