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Table 4 Evaluation of 24-h urinary calcium changes by modulating the effects of confounding variables

From: Effect of two vitamin D repletion protocols on 24-h urine calcium in patients with recurrent calcium kidney stones and vitamin D deficiency: a randomized clinical trial

Variables

β (95% CI)

p- value

Study group

  

50,000 IU/weekly

-7.485 (− 41.27, 26.30)

0.664

2000 IU/daily

Reference

 

Time

  

After treatment

44.014 (16.48, 71.54)

0.002**

Before treatment

Reference

 

Gender

  

Male

− 14.955 (− 52.40, 22.49)

0.434

Female

Reference

 

Age, years

-1.436 (− 2.93, 0.06)

0.061

24-U citrate (mg/24 h)

0.025 (− 0.01, 0.06)

0.175

24-U sodium (mg/24 h)

0.212 (− 0.01, 0.43)

0.062

Serum PTH (pg/mL)

− 0.199 (− 0.91, 0.51)

0.586

Serum 25(OH)D (ng/mL)

1.424 (− 0.66, 3.51)

0.182

Dietary calcium (mg)

− 0.001 (− 0.05, 0.05)

0.977

Dietary protein intake (gr)

− 0.259 (− 1.38, 0.87)

0.653

Protein food group

− 0.259 (− 1.38, 0.87)

0.653

Kidney stone duration, years

0.909 (− 0.79, 2.61)

0.297

  1. CI, confidence interval; PTH, parathyroid hormone; 25(OH)D, 25-hydroxyvitamin D
  2. **p < 0.01. Bold values emphasize statistical significance
  3. Regression coefficient (β) were reported along with 95% confidence interval. The β (regression coefficient) signifies how much the mean of a dependent variable (for example the level of serum parathyroid hormone) changes when the participants received loading vitamin D repletion therapy (50,000 IU cholecalciferol/oral/ weekly) compared with the maintenance vitamin D repletion protocol (2000 IU cholecalciferol/oral/daily)