Table 5 Some Studies on the effect of vitamin D repletion therapy on the 24-hour urine calcium in kidney stone formers
References | Study methodology | Vitamin D repletion dose | Sample size | Baseline 25-OH D (ng/ml) | Study time | 24-Urine calcium (mg/day) | Other main findings 25-OH D (ng/ml) PTH |
|---|---|---|---|---|---|---|---|
Vitale et al. [7] | Retrospective | Oral bolus of 100,000–200,000 IU; followed by 5000–10,000 IU/weekly OR, 25,000–50,000 IU/monthly | 33 | < 20 | 6 months | Significant increase (p < 0.01) | Significant 25(OH)D mean increase; 11.8 to 40.2 (p < 0.01) Significant PTH decrease (p < 0.01) |
Ganji et al. [8] | Non-controlled clinical trial | 50,000 IU/weekly/ for 8 weeks followed by 50,000 IU/ every forth night | 30 | < 30 | 3 months | No significant increase (p = 0.39) | Significant 25(OH)D mean increase; 10.4 to 44.0 (p < 0.001) Significant PTH decrease (p < 0.001) |
Taheri et al. [9] | Retrospective | 50,000 IU/weekly | 26 | < 30 | 8–12 weeks | Significant increase (p < 0.001) | Significant 25(OH)D mean increase from 14.1 to 33.6 (p < 0.001) Significant PTH decrease (p < 0.001) |
Ferroni et al. [5] | Randomized controlled trial | 1,000 IU/daily (8 patients) OR, 50,000 IU/weekly (13 patients) | 21 | < 30 | 6 weeks | No significant increase§ (p > 0.05) | Significant 25(OH)D increase only in 50,000 IU group (p < 0.01) PTH: Not evaluated |
Hesswani et al. [10] | Retrospective | 1000 IU Vitamin D/daily + 945 mg Calcium /daily† | 34 | < 30 | 39 months‡ | Significant increase (p < 0.001) | Significant 25(OH)D mean increase from 20.83 to 26.60, (p < 0.001) No significant PTH change (p = 0.98) |
Leaf et al. [6] | Non-controlled clinical trial | 50,000 IU/weekly | 29 | < 30 | 8 weeks | No significant increase (p = 0.91) | Significant 25(OH)D mean increase from 17 to 35, (p < 0.001) No significant PTH change (p = 0.71) |