Fig. 1
Cisplatin-induced POF mouse model. A Vaginal exfoliative cell smear from normal mice and POF mice. B Bar graph illustrating the body weight of mice with or without cisplatin treatment. C Comparison of the ovarian size and weight ratio between the control and POF groups. D Serum concentration of E2 and FSH determined by ELISA in the control and POF groups. Control group, n = 10; POF group, n = 10. POF: premature ovarian failure; E2: estradiol; FSH: follicle-stimulating hormone; ELISA: enzyme-linked immunosorbent assay. *P < 0.05; ***P < 0.001, two-tailed Student’s t test. Scale bar, 100 μm