Fig. 6From: Research progress on the GRP78 gene in the diagnosis, treatment and immunity of cervical cancerWhen endoplasmic reticulum stress occurs, GRP78, UPR, PERK, iREα and ATF6 increase, which activates CHOP, caspase-3 and caspase-12, thereby inhibiting the expression of Bcl-2 and inducing apoptosis. GRP78 activates the JNK and P38 signaling pathways as well as induces apoptosisBack to article page