Table 1 Natural products as inducer of GRP78 in cervical cancer cells
From: Research progress on the GRP78 gene in the diagnosis, treatment and immunity of cervical cancer
Nature products | Pharmacological effect | Cervical cells |
|---|---|---|
Dicerandrol from endophytic fungus, Phomopsis sp. Hesperidin from citrus fruits | G2/Mell cycle arrest Induce apoptosis induce ROS G0/G1cycle arrest cyclinD1 cyclinE1 inhibit | HeLa cells [91] |
| Â | Activate Caspase-3 induce apoptosis | HeLa cells [92] |
Sesamin from sesamum indicun | Induce apoptosis Caspase-2,GADD153, RE1α, -IRE1α, NK p-JNK Induce autophagy LC3I/II, Beclin-1 | HeLa cells [62] HeLa cells [93] |
Isoliquiritigenin From iquorice | Induce ROS Induce apoptosis Caspase-12 | Â |
3alpha,23-sopropylidenedioxyolean-12-en-27-oic acid (IPA) | Induce apoptosis Caspase-3,8,9 Mui-calpain GADD153 | HeLa Cells [94] |
Genistein from soybeans | Induce apoptosis Caspase-3 CHOP | HeLa cells [95] |
Gambogic acid from Garcinia hanburyi | Induce apoptosis Caspas3,8,9, JNK | HeLa cells [96] |