Fig. 6

Exosomal NOX1 promotes tumor growth and M2 macrophage infiltration in vivo by stimulating ROS production. A Experiments on tumor-bearing nude mice. B IHC analysis of Ki67 expression. C Fluorescence confocal microscopy-based detection of iNOS and CD68 expression. D Fluorescence confocal microscopy-based detection of CD68 and CD163 expression. Scale bar, 50 µm; Con, control; NC, negative control; OE, NOX1 overexpression; Ace, Acetylcysteine; exo, exosome; GW4869, inhibitor of exosome biogenesis/release