Table 1 The function and mechanisms of fisetin in cancer
From: Biological effects and mechanisms of fisetin in cancer: a promising anti-cancer agent
cancer | Function | Signaling pathway |
|---|---|---|
Liver cancer | Resist proliferation, migration and invasion, induce apoptosis, attenuate ROS and inflammation | VEGF, MAPK, caspase 3 |
Lung cancer | Promote apoptosis and ER stress, induce autophagic cell death, induce mitotic catastrophe, enhance chemotherapeutic effects, resist proliferation, suppress migration and invasion | PI3K/AKT/mTOR, Caspase 3, TRAIL, MAPK |
Oral cancer | Induce apoptosis and autophagy, promote ER stress and ROS, suppress proliferation | cytochrome c, AIF and ENDO G, caspase 3, Met/Src |
Gastric cancer | Reduce proliferation, induce apoptosis and ROS | CDK, ERK |
Ovarian cancer | Induce apoptosis, reduce proliferation | Â |
Prostate cancer | Inhibit the viability and colony formation, promote apoptosis, enhance chemotherapeutic effects, induce autophagic cell death, resist proliferation | β-tubulin, PI3K/Akt, JNK, mTOR, TRAIL, YB-1, MMP-2/9 |
Breast cancer | Promote apoptosis and invasion and metastasis, enhance chemotherapeutic effects, induce autophagy | PI3K/Akt/mTOR, PARP. HO-1, caspase-3, PTEN/Akt/GSK3β, HER2/neu, PKC/ROS/MAPK, p53, caspase-7, -8 and -9 |
Colorectal cancer | Enhance radiosensitivity, induce apoptosis, suppress proliferation, resist angiogenesis | AKT, COX, Wnt/EGFR/NF-κB, p53 |
Osteosarcoma | Inhibit proliferation, enhance chemotherapeutic effects | Â |
Renal cancer | Induce apoptosis, inhibit proliferation and invasion | P53, TET1, 5hmC |
Pancreatic cancer | Enhance chemotherapeutic effects, induce autophagy | ERK-MYC, AMPK/mTOR |
Cervical cancer | Induce apoptosis, inhibit migration and invasion | Caspase-3/8, ERK1/2 |
Glioma | Suppress proliferation, inhibit invasion and migration | MAPK |
Laryngeal carcinoma | Inhibit proliferation, induce apoptosis and autophagy | ERK1/2, AKT/NF-Κb/mTOR |
Bladder cancer | Inhibit proliferation, induce apoptosis | P53, NF-κB |
Nasopharyngeal carcinoma | Prevent migration and invasion | LMP1 |
Leucocythemia | Inhibit proliferation, induce apoptosis and cell cycle arrest, enhance chemotherapeutic effects | Caspase 3, JAK/STAT, MAPK, NO |
Skin cancer | Reduce proliferation, inhibit inflammation, induce ROS, have anti-invasive and anti-metastatic effects, enhance chemotherapeutic effects, induce apoptosis and ER stress | P53, p21, PI3K/AKT/mTOR, NF-κB, Nrf2, MAPK, p70S6K,PARP, Wnt/β-catenin |