The cause and effect of gut microbiota in development of inflammatory disorders of the breast

Table 1 MR estimates for the association between gut microbiota and IDB

Exposure	Method	No. of SNP	F-statistic	OR	95%CI	p-value
Eubacterium rectale group	MR Egger	7	213.61	2.18	0.22–21.47	0.53
	Weighted median	7		1.48	0.72–3.06	0.28
	IVW	7		1.87	1.02–3.43	4.20E−02
	Simple mode	7		1.11	0.39–3.19	0.85
	Weighted mode	7		1.22	0.47–3.16	0.7
Bifidobacterium	MR Egger	19	611.71	0.38	0.17–0.83	2.70E−02
	Weighted median	19		0.95	0.66–1.37	0.79
	IVW	19		0.98	0.71–1.34	0.88
	Simple mode	19		1.24	0.65–2.37	0.52
	Weighted mode	19		1.02	0.63–1.65	0.94
Olsenella	MR Egger	9	191.85	1.36	0.48–3.85	0.58
	Weighted median	9		1.34	0.99–1.81	0.06
	IVW	9		1.29	1.02–1.64	3.30E−02
	Simple mode	9		1.48	0.93–2.37	0.14
	Weighted mode	9		1.49	0.93–2.38	0.14
Peptococcus	MR Egger	13	387.2	0.70	0.26–1.84	0.48
	Weighted median	13		0.81	0.59–1.11	0.19
	IVW	13		0.75	0.60–0.94	1.30E−02
	Simple mode	13		0.81	0.49–1.36	0.45
	Weighted mode	13		0.83	0.51–1.34	0.45
Prevotella7	MR Egger	11	249.45	1.02	0.18–5.71	0.98
	Weighted median	11		1.38	1.01–1.89	4.60E−02
	IVW	11		1.17	0.89–1.56	0.26
	Simple mode	11		1.54	0.83–2.85	0.2
	Weighted mode	11		1.52	0.82–2.82	0.22
Ruminiclostridium-6	MR Egger	14	314.03	1.27	0.54–2.98	0.59
	Weighted median	14		1.62	1.00–2.65	0.05
	IVW	14		1.53	1.08–2.17	1.60E−02
	Simple mode	14		1.58	0.74–3.36	0.25
	Weighted mode	14		1.63	0.86–3.10	0.16
Ruminococcaceae UCG003	MR Egger	10	268.82	2.87	0.78–10.57	0.15
	Weighted median	10		1.79	1.04–3.07	3.40E−02
	IVW	10		1.40	0.92–2.15	0.12
	Simple mode	10		2.04	0.89–4.65	0.13
	Weighted mode	10		2.08	0.94–4.61	0.11

IDB inflammatory disorders of the breast, GM gut microbiota, SNP single nucleotide polymorphism, OR odds ratio, CI confidence interval, IVW inverse variance weighted, MR Mendelian randomization

ISSN: 2047-783X