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Fig. 6 | European Journal of Medical Research

Fig. 6

From: Neddylation inhibitor MLN4924 sensitizes head and neck squamous carcinoma cells to (S)-10-hydroxycamptothecin

Fig. 6

MLN4924 combined with 10-HCPT has synergistic cytotoxic effects on AMC-HN-8 cells. A Heat map showing gene expression of AMC-HN-8 from RNA sequencing after treatment with 10-HCPT with or without MLN4924 for 24 h. B Box plot showing gene expression of NEDD8 and TOP1 in different experimental groups [log2(FPKM + 1)]; *p < 0.05. C Bar plot of gene ontology enrichment analyses of upregulated genes in the combination group. D Summary of enrichment analysis in TRRUST

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European Journal of Medical Research

ISSN: 2047-783X

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