Fig. 1

The workflow of this study. VZV and IS samples were obtained from GSE175797, GSE173719, GSE16561, and GSE22255. Common DEGs were identified from four datasets using the R language. GO identification, KEGG pathway, PPI network, hub genes, TF and miRNA analysis, and medication screening was performed based on the common DEGs. Finally, molecular docking and molecular dynamics simulations were used to validate the resveratrol and hub genes