Fig. 1
From: Neurological manifestations of SARS-CoV-2: complexity, mechanism and associated disorders
Diagram of different barriers of the brain (potential pathways for neuroinvasion). A Brain–CSF barrier. Neuroinvasion from CSF to the cerebral cortex through epithelial cells (free flow in the adult brain) [24]. B Blood–brain–meningeal barrier. Meningeal invasion of the virus from BV to various layers(may lead to viral meningitis) [25]. C Blood–brain barrier. Potential BBB (capillary endothelial cells with TJ)-mediated invasion of SARS-CoV-2 in the central nervous system [24]. D Blood–CSF barrier. Potential blood–CSF barrier-mediated SARS-CoV-2 neuroinfiltration in the central nervous system(through the BM and ependymal cells) [26]. (BV—blood vessel; TJ—tight junctions; BM—basement membrane; CSF—the cerebrospinal fluid)