Fig. 2
From: Neurological manifestations of SARS-CoV-2: complexity, mechanism and associated disorders
A Endothelium is covered by pericytes and astrocytic end-feet, which secrete the matrix proteins that make up the basement membrane. Neurons, pericytes, and astrocytes surrounding the blood capillary are shown. Astrocytes are stacked around the brain's blood arteries and are considered to be in charge of moving ions out of the brain. Due to their integration into the basement membrane micro vessels, pericytes strongly connect with the endothelial cells that make up the BBB. They provide structural integrity to the micro vessels. B Cross-sectional view of the blood vessel and schematic representation of layers present in the blood–brain barrier shows the outermost astrocytes separated from endothelial cells and tight junctions within these cells by a basement membrane [30]