Fig. 6
From: Neurological manifestations of SARS-CoV-2: complexity, mechanism and associated disorders
SARS-CoV-2 infects the host through binding to ACE2 receptors on endothelial cells, causing systemic and vascular inflammation, as well as monocyte activation and the release of pro-inflammatory cytokine storm. Neutrophil recruitment and tissue factor (TF) activation occur as a result. Continuous recruitment of neutrophils releases the Neutrophil Extracellular Trap (NET), which promotes thrombosis. The TF subsequently attaches to the coagulation factor VII (FVII), which activates the coagulation process. vWF (von Willebrandfactor) is released, and platelets are activated, which further accelerate coagulation [93, 98]