Table 4 Univariate and multivariate Cox analyses for PFS of UTUC patients
Variable | Univariate cox analysis | Multivariate cox analysis | ||||
|---|---|---|---|---|---|---|
HR | 95%CI | p value | HR | 95%CI | p value | |
Sex | ||||||
Female | Reference | Reference | ||||
Male | 1.335 | 1.029–1.732 | 0.030 | 1.220 | 0.928–1.640 | 0.154 |
Age | ||||||
< 65 | Reference | Reference | ||||
≥ 65 | 1.435 | 1.065–1.933 | 0.018 | 1.393 | 1.001–1.937 | 0.049 |
BMI | ||||||
< 25 | Reference | |||||
≥ 25 | 0.864 | 0.662–1.128 | 0.282 | |||
Side | ||||||
Left | Reference | |||||
Right | 1.094 | 0.843–1.419 | 0.499 | |||
Site | ||||||
Pelvis | Reference | Reference | ||||
Ureter | 1.617 | 1.228–2.130 | 0.001 | 1.520 | 1.107–2.089 | 0.010 |
Both | 1.000 | 0.567–1.766 | 0.999 | 0.787 | 0.438–1.412 | 0.421 |
Approach | ||||||
Open | Reference | |||||
Laparoscopic | 1.163 | 0.892–1.517 | 0.265 | |||
Ureteroscopy | ||||||
No | Reference | Reference | ||||
Yes | 1.489 | 1.051–2.111 | 0.025 | 1.250 | 0.856–1.827 | 0.248 |
Hydronephrosis | ||||||
No | Reference | Reference | ||||
Yes | 1.544 | 1.110–2.148 | 0.010 | 1.039 | 0.713–1.515 | 0.842 |
Multifocality | ||||||
No | Reference | |||||
Yes | 1.038 | 0.721–1.493 | 0.842 | |||
Size | ||||||
< 5 | Reference | |||||
≥ 5 | 1.217 | 0.841–1.762 | 0.298 | |||
LVI | ||||||
No | Reference | Reference | ||||
Yes | 2.467 | 1.764–3.451 | < 0.001 | 1.708 | 1.142–2.554 | 0.009 |
Tis | ||||||
No | Reference | |||||
Yes | 0.927 | 0.492–1.748 | 0.815 | |||
T stage | ||||||
T1 | Reference | Reference | ||||
T2 | 1.823 | 1.240–2.679 | 0.002 | 1.438 | 0.899–2.020 | 0.148 |
T3 | 2.098 | 1.457–3.021 | < 0.001 | 1.610 | 1.079–2.403 | 0.020 |
T4 | 5.538 | 3.134–9.785 | < 0.001 | 2.111 | 1.049–4.244 | 0.036 |
Margin | ||||||
Negative | Reference | Reference | ||||
Positive | 2.308 | 1.135–4.694 | 0.021 | 1.727 | 0.860–3.468 | 0.125 |
N stage | ||||||
pN0&Nx | Reference | Reference | ||||
pN + | 4.302 | 2.858–6.476 | < 0.001 | 2.767 | 1.747–4.382 | < 0.001 |
Grade | ||||||
Low | ||||||
High | 1.809 | 1.280–2.556 | 0.001 | 1.432 | 0.982–2.061 | 0.062 |
Chemotherapy | ||||||
No | Reference | |||||
Yes | 1.177 | 0.841–1.647 | 0.342 | |||
SOSI | ||||||
Low risk | Reference | Reference | ||||
High risk | 1.721 | 1.303–2.273 | < 0.001 | 1.430 | 1.055–1.937 | 0.021 |