Table 2 Treatment characteristics of the included studies
Author(years) | Concurrent chemoradiotherapy weekly regimen triweekly regimen | Median cumulative cisplatin dose weekly regimen triweekly regimen | Radiotherapy | Therapeutic schedule | Outcomes | ||
|---|---|---|---|---|---|---|---|
Zhu (2018) | Cisplatin 40 mg/m2 based on oncologists’ opinions | Cisplatin 100 mg/m2d1,d22,d43 | 229.20 mg/m2 | 228.00 mg/m2 | IMRT; dose:NA | CCRT alone | DFS,DMFS,LRRFS,OS |
Xia (2021) | Cisplatin 40Â mg/m2 for six cycles | Cisplatin 100Â mg/m2 for two cycles | 220.00Â mg/m2 | 200.00Â mg/m2 | IMRT; ose:NA | CCRT alone | FFS,OS,DMFS,LRFS,ORR |
Wang (2019) | Cisplatin 30–40 mg/m2 d1,d8,d15,d22,d29,d36, d43 | Cisplatin 80–100 mg/m2 d1,d22,d43 | 190. 54 mg/m2 | 202.97 mg/m2 | IMRT; dose:66–72 Gy | CCRT alone | OS,DFS,LRFS,DMFS |
Meng (2018) | Cisplatin 30–40 mg/m2 weekly | Cisplatin 80 mg/m2 every 3 weeks | 171.00 mg/m2 | 168.20 mg/m2 | IMRT; dose:66–72 Gy | CCRT alone | OS,DFS,LRRFS, DMFS |
Lee (2015) | Cisplatin 40 mg/m2 d1,d8,d15,d22,d29,d36, d43 | Cisplatin 100 mg/m2 d1,d22,d43 | 248.90 mg/m2 | 256.60 mg/m2 | 3D-CRT or IMRT; dose:at least 66 Gy | CCRT + AC | PFS,OS,ORR,QOL, toxicity |
Jagdis (2014) | Cisplatin 40 mg/m2 weekly for 7 week | Cisplatin 100 mg/m2 d1,d22,d43 | 230.00 mg/m2 | 249.00 mg/m2 | 3D-CRT or IMRT; dose:at least 66 Gy | CCRT + AC | OS,DFS |
Gundog (2019) | Cisplatin 50Â mg/m2 weekly | Cisplatin 100Â mg/m2 every 3Â weeks | NA | NA | 2/3D-CRT or IMRT; dose:70Â Gy | CCRT alone | OS,LRFS,DMFS, ORR |