Lymphangiogenesis in gastric cancer: function and mechanism

Table 1 Gastric cancer-related lymphangiogenesis molecules

Year	Molecule	Function	Mechanism or associated molecules	References
2010	NRP2	Accelerator	NRP2/VEGF-C/VEGFR3	[20]
2011	Shh	Accelerator	Shh/PI3K/Akt/EMT,MMP-9	[29]
	Id-1	Inhibitor	–	[140]
	HGF	Accelerator	HGF/c-Met	[25]
	iNOS	Accelerator	LVD	[137, 138]
2012	EphA3	Accelerator	–	[129]
	CXCL1	Accelerator	CXCL1/NF-ҡB, FAK-ERK1/2-RhoA, F-actin	[65]
	SOX 18	Accelerator		[141]
2013	CNTN-1	Accelerator	CNTN-1/VEGF-C, VEGFR-3	[142]
2013	ROSI	Inhibitor	ROSI/VEGF-C, VEGFR-3	[143]
2014	ECM1	Accelerator	ECM1/LMVD	[144]
	TP	Accelerator	–	[145]
	KAI1	Inhibitor	KAI1/MVD, LVD	[146]
2015	MACC1	Accelerator	MACC1/HGF/c-Met/VEGF-C/D	[27]
	claudin 4	Inhibitor	–	[147]
	IL-8	Accelerator	IL-8/VEGF-C, VEGF-D, VEGFR-3	[148]
2016	IL-6	Accelerator	IL-6/JAK-STAT3-VEGF-C	[44]
	RNF180	Inhibitor	RNF180/VEGF-C, D, CXCL7	[136]
	TAMs	Accelerator	VEGF-C, LVD	[118]
2017	PROX1	Accelerator	PROX1/b-catenin, ERK1/2, p38, JNK	[134]
2017	KLHL6	Accelerator	KLHL6/HGF, MMP-2和VEGF-C	[135]
2018	Kallistatin	Inhibitor	Kallistatin/NF-ҡB/VEGF-C	[114]
	COX-2	Accelerator	COX-2/VEGF-C	[127]
	PTBP3	Accelerator	PTBP3/CAV1	[131]
2019	oxLDL	Accelerator	oxLDL/NF-ҡB/VEGF-C	[115]
	Macrophage	Accelerator	VEGF-A/VEGF-C/VEGF-D	[68]
	HMGB1	Accelerator	HMGB1/VEGF-D	[149]
	HOXB9	Accelerator	HOXB9/VEGF-D	[150]
	MicroRNA-7	Inhibitor	MicroRNA-7/NF-κB/VEGF	[151]
2020	GREM1	Accelerator	GREM1/VEGFC, PDPN, LYVE	[152]
	BMPRs	Accelerator	–	[42]
	LncRNA-HNF1A-AS1	Accelerator	LncRNA-HNF1A-AS1/miR-30b-3p/PI3K/AKT	[153]
2021	SOAT1	Accelerator	SOAT1/SREBP1, SREBP2/VEGF-C	[116]
2022	hsa_circ_0000437	Accelerator	hsa_circ_0000437/HSPA2-ERK	[131]
2022	lncRNA ANRIL	Accelerator	lncRNA ANRIL/VEGF-C/VEGFR-3	[154]

ISSN: 2047-783X