Table 2 Univariable and multivariable cox model for OS
Parameter | Univariate | Multivariate | ||
|---|---|---|---|---|
HR (95% CI) | p-value | HR (95% CI) | p-value | |
Age | < 0.001a | 0.005 | ||
< 60 | 1 | 1 | ||
≥ 60 | 1.350 (1.141,1.597) | 1.282 (1.079,1.523) | ||
Sex | 0.344 | |||
Female | 1 | |||
Male | 1.076 (0.925,1.251) | |||
Primary tumor site | 0.001 | 0.001 | ||
Intrahepatic bile duct | 1 | 1 | ||
Extrahepatic bile duct | 1.451 (1.142,1.845) | 0.002 | 1.487 (1.115,1.983) | 0.007 |
Gallbladder | 1.557 (1.228,1.973) | < 0.001 | 1.615 (1.241,2.102) | < 0.001 |
T stage | < 0.001 | < 0.001 | ||
T1 | 1 | 1 | ||
T2 | 1.278 (0.972,1.681) | 0.078 | 1.113 (0.827,1.497) | 0.481 |
T3 | 1.895 (1.453,2.471) | < 0.001 | 1.619 (1.212,2.164) | 0.001 |
T4 | 1.984 (1.444,2.725) | < 0.001 | 1.803 (1.273,2.555) | 0.001 |
N stage | < 0.001 | < 0.001 | ||
N0 | 1 | 1 | ||
N1 | 1.400 (1.203,1.631) | < 0.001 | 1.524 (1.281,1.813) | < 0.001 |
Nx | 3.172 (1.413,7.122) | 0.005 | 1.863 (0.805,4.312) | 0.146 |
Tumor size | 0.003 | 0.008 | ||
< 5 cm | 1 | 1 | ||
≥ 5 cm | 1.264 (1.082,1.477) | 1.251 (1.060,1.477) | ||
# of removed lymph nodes | 0.001 | < 0.001 | ||
0 | 1 | 1 | ||
1–3 | 0.688 (0.561,0.844) | < 0.001 | 0.585 (0.467,0.733) | < 0.001 |
≥ 4 | 0.711 (0.589,0.859) | < 0.001 | 0.516 (0.408,0.652) | < 0.001 |
NA | 0.992 (0.594,1.655) | 0.974 | 0.684 (0.404,1.159) | 0.158 |
Grade | 0.006 | 0.090 | ||
I: Well differentiated | 1 | 1 | ||
II: Moderately differentiated | 1.329 (1.021,1.731) | 0.035 | 1.306 (0.998,1.709) | 0.051 |
III: Poorly differentiated | 1.603 (1.224,2.099) | 0.001 | 1.436 (1.091,1.889) | 0.010 |
IV: Undifferentiated; anaplastic | 1.636 (0.935,2.862) | 0.085 | 1.591 (0.904,2.800) | 0.107 |
NA | 1.560 (1.105,2.202) | 0.011 | 1.419 (1.000,2.015) | 0.050 |
Treatment | 0.142 | 0.019 | ||
CT | 1 | 1 | ||
CRT | 0.893 (0.768,1.039) | 0.823 (0.704,0.963) | ||