Table 4 Univariable and multivariable cox model for OS in the propensity-score matching cohort
Parameter | Univariate | Multivariate | ||
|---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | |
Age | 0.006a | 0.025 | ||
< 60 | 1 | 1 | ||
≥ 60 | 1.322 (1.084,1.613) | 1.264 (1.030,1.550) | ||
Sex | 0.305 | |||
Female | 1 | |||
Male | 1.095 (0.921,1.303) | |||
Primary tumor site | 0.002 | 0.002 | ||
Intrahepatic bile duct | 1 | |||
Extrahepatic bile duct | 1.531 (1.105,2.120) | 0.010 | 1.534 (1.065,2.209) | 0.021 |
Gallbladder | 1.708 (1.241,2.351) | 0.001 | 1.794 (1.282,2.510) | 0.001 |
T stage | < 0.001 | < 0.001 | ||
T1 | 1 | 1 | ||
T2 | 1.240 (0.884,1.741) | 0.213 | 1.006 (0.700,1.445) | 0.975 |
T3 | 1.824 (1.313,2.536) | < 0.001 | 1.485 (1.047,2.106) | 0.027 |
T4 | 1.964 (1.344,2.869) | < 0.001 | 1.840 (1.221,2.773) | 0.004 |
N stage | < 0.001 | < 0.001 | ||
N0 | 1 | 1 | ||
N1 | 1.403 (1.178,1.672) | < 0.001 | 1.507(1.237,1.837) | < 0.001 |
Nx | 3.051 (1.355,6.870) | 0.007 | 1.958 (0.837,4.579) | 0.121 |
Tumor size | 0.017 | 0.038 | ||
< 5 cm | 1 | 1 | ||
≥ 5 cm | 1.242 (1.040,1.485) | 1.222 (1.011,1.477) | ||
# of removed lymph nodes | 0.004 | < 0.001 | ||
0 | 1 | 1 | ||
1–3 | 0.745 (0.589,0.943) | 0.014 | 0.655 (0.506,0.848) | 0.001 |
≥ 4 | 0.668 (0.536,0.831) | < 0.001 | 0.507 (0.387,0.663) | < 0.001 |
NA | 0.950 (0.556,1.621) | 0.850 | 0.698 (0.402,1.212) | 0.201 |
Grade | 0.004 | 0.153 | ||
I: Well differentiated | 1 | 1 | ||
II: Moderately differentiated | 1.375 (1.017,1.860) | 0.039 | 1.307 (0.959,1.782) | 0.090 |
III: Poorly differentiated | 1.680 (1.239,2.278) | 0.001 | 1.452 (1.062,1.986) | 0.020 |
IV: Undifferentiated; anaplastic | 2.386 (1.212,4.697) | 0.012 | 1.854 (0.932,3.688) | 0.078 |
NA | 1.608 (1.083,2.389) | 0.019 | 1.371 (0.916,2.050) | 0.125 |
Treatment | 0.082 | 0.032 | ||
CT | 1 | 1 | ||
CRT | 0.857 (0.721,1.020) | 0.824 (0.691,0.984) | ||